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US 8,796,330 B2Granted
Inhibitors of histone deacetylase and prodrugs thereof
AssigneeMethylGene Inc.
InventorsRobert Déziel, Alain Ajamian
Life of this patent
Estimating the term…
Abstract
The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
Claims3
A compound selected from the group consisting of
- N-(1-aminocyclopropanecarbonyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide hydrochloride;
- (S)-N-(2-amino-3-phenylpropanoyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide hydrochloride;
- (S)-N-(2-amino-3-methylbutanoyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide hydrochloride;
- (S)-N-(2-amino-3,3-dimethylbutanoyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide hydrochloride;
- N-(1-aminocyclobutanecarbonyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide hydrochloride;
- N-(2-amino-2-methylpropanoyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide hydrochloride;
- N-(1-(aminomethyl)cyclopropanecarbonyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide hydrochloride;
- (S)-N-(2,6-diaminohexanoyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide;
- N-(2-hydroxyacetoxy)-2-(4-(4-phenylbutyl)phenyl)acetamide;
- (S)-N-(2-amino-5-guanidinopentanoyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide;
- (S)-2,6-diamino-N-(1-((2-(4-(4-phenylbutyl)phenyl)acetamidooxy)carbonyl)cyclopropyl)hexanamide;
- N-(1-((2-(4-(4-phenylbutyl)phenyl)acetamidooxy)carbonyl)cyclopropyl)nicotinamide;
- (S)-2-amino-3-methyl-N-(1-((2-(4-(4-phenylbutyl)phenyl)acetamidooxy)carbonyl)cyclopropyl)butanamide;
- (S)-2-amino-3-phenyl-N-(1-((2-(4-(4-phenylbutyl)phenyl)acetamidooxy)carbonyl)cyclopropyl)propanamide;
- 2-(4-(4-phenylbutyl)phenyl)-N-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)acetamide;
- and
- N-(2,3-dihydroxypropanoyloxy)-2-(4-(4-phenylbutyl)phenyl)acetamide.
14 more elements
A pharmaceutically acceptable salt of a species selected from the group consisting of
- 1-methyl-3-(3-oxo-3-(2-(4-(4-phenylbutyl)phenyl)acetamidooxy)propyl)pyridinium, 1-methyl-4-(3-oxo-3-(2-(4-(4-phenylbutyl)phenyl)acetamidooxy)propyl)-4H-1,2,4-triazol-1-ium, and
- 1-methyl-3-((2-(4-(4-phenylbutyl)phenyl)acetamidooxy)carbonyl)pyridinium.
Dependencies are inferred from the claim text.