Defensin-like molecules as novel antimicrobial agents
AssigneeUniversity of Maryland, Baltimore
InventorsErik De Leeuw, Alexander D. MacKerell
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Abstract
Disclosed are methods of treating and/or preventing infections in mammals caused by microorganisms, by administering to a mammal a therapeutically effective amount of at least one defensin-like molecule, e.g., in a composition that includes such molecule. Also disclosed are the use of such defensin-like molecules for treating and/or preventing infections in mammals; and kits that may include such molecules, or compositions that include such molecules, as well as instructions for using such molecules to treat a mammal.
Claims6
A method of treating infections in mammals caused by microorganisms, comprising administering to a mammal a therapeutically effective amount of
- 2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-4,6-diphenyl-pyran-3-ylium
- wherein said microorganisms comprise one or more gram-positive bacteria selected from the group consisting of Staphylococcus, Streptococcus, and Enterococcus.
A method of killing a bacterial population in a mammal comprising administering to a mammal a therapeutically effective amount for killing the bacterial population in the mammal, of:
- 2-[(E)-2-[4-(dimethylamino)phenyl]ethenyl]-4,6-diphenyl-pyran-3-ylium
- wherein said bacterial population comprises a population of one or more gram-positive bacteria selected from the group consisting of Staphylococcus, Streptococcus, and Enterococcus.
Dependencies are inferred from the claim text.