Heteroaryls and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is —R1b, —V1—R1c, -T1-R1b, or —V1-T1-R1b wherein:
• V1 is —NR1a—, —NR1a—C(O)—, —NR1a—C(S)—, —NR1a—C(NR1a)—, NR1aC(O)O—, NR1aC(O)NR1a—, NR1aC(O)S—, NR1aC(S)O—, NR1aC(S)NR1a—, NR1aC(S)S—, —NR1aC(NR1a)O—, —NR1aC(NR1a)NR1a—, —NR1aS(O)2—, —NR1aS(O)2NR1a—, —C(O)—, —CO2—, —C(O)NR1a—, C(O)NR1aO—, —SO2—, or —SO2NR1a—;
• each occurrence of R1a is independently hydrogen or an optionally substituted group selected from C1-6aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• T1 is an optionally substituted C1-C6 alkylene chain wherein the alkylene chain optionally is interrupted by —N(R1a)—, —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —C(O)O—, C(O)N(R1a)—, —S(O)2N(R1a)—, —OC(O)N(R1a)—, —N(R1a)C(O)—, —N(R1a)SO2—, —N(R1a)C(O)O—, —NR1aC(O)N(R1a)—, —N(R1a)S(O)2N(R1a) OC(O)—, or —C(O)N(R1a)—O— or wherein T1 forms part of an optionally substituted 3-7 membered cycloaliphatic or heterocyclyl ring;
• each occurrence of R1b is independently hydrogen, halogen, —CN, —NO2, —N(R1a)2, —OR1a, —SR1a, —S(O)2R1a, —C(O)R1a, —C(O)OR1a, —C(O)N(R1a)2, —S(O)2N(R1a)2, —OC(O)N(R1a)2, —N(R1a)C(O)R1a, —N(R1a)SO2R1a, —N(R1a)C(O)OR1a, —N(R1a)C(O)N(R1a)2, or —N(R1a)SO2N(R1a)2, or an optionally substituted group selected from 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each occurrence of R1c is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or
• R1a and R1c taken together with a nitrogen atom to which they are bound form an optionally substituted 4-7-membered heterocyclyl ring having 0-1 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• R2 is halogen, —W—R6, or —R6, wherein:
• W is —O—, N(R2a)—, —S—, —S(O)—, —S(O)2—, —C(O)—, —CO2—, —C(O)NR2a—, —N(R2a)C(O)—, —N(R2a)CO2—, —S(O)2NR2a—, —N(R2a)S(O)2—, —OC(O)N(R2a)—, —N(R2a)C(O)NR2a—, —N(R2a)S(O)2N(R2a)—, or —OC(O)—;
• R2a is hydrogen or an optionally substituted C1-4 aliphatic, and
• R6 is an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• R3 is H, —CN, halogen, —Z—R5, C1-6 aliphatic, or 3-10-membered cycloaliphatic, wherein:
• Z is selected from an optionally substituted C1-3 alkylene chain, —O—, —N(R3a)—, —S—, —S(O)—, —S(O)2—, —C(O)—, —CO2—, —C(O)NR3″-, —N(R3a)C(O)—, —N(R3a)CO2—, —S(O)2NR3a—, —N(R3a)S(O)2—, —OC(O)N(R3a)—, —N(R3a)C(O)NR3a—, —N(R3a)S(O)2N(R3a)—, or —OC(O)—;
• R3a is hydrogen or an optionally substituted C1-4 aliphatic, and
• R5 is an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each occurrence of R4 and R4′ is independently H, —Z—R6, C1-6 aliphatic, or 3-10-membered cycloaliphatic, wherein:
• Z is selected from an optionally substituted C1-3 alkylene chain, —O—, —N(R4a)—, —S(O)—, —S(O)2—, —C(O)—, —CO2—, —C(O)NR4a—, —N(R4a)C(O)—, —N(R4a)CO2—, —S(O)2NR4a—, —N(R4a)S(O)2—, —OC(O)N(R4a)—, —N(R4a)C(O)NR4a—, —N(R4a)S(O)2N(R4a)—, or —OC(O)—;
• R4a is hydrogen or an optionally substituted C1-4 aliphatic, and
• R6 is an optionally substituted group selected from C1-6aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• and
• X1, X2, X3, X4, X5 and X6 are each independently N or CR7, wherein each occurrence of R7 is independently hydrogen, —CN, halogen, —Z—R8, optionally substituted C1-6aliphatic, or optionally substituted 3-10-membered cycloaliphatic, wherein:
• Z is selected from an optionally substituted C1-3 alkylene chain, —O—, —N(R7a)—, —S—, —S(O)—, —S(O)2—, —C(O)—, —CO2—, —C(O)NR7a—, —N(R7a)C(O)—, —N(R7a)CO2—, —S(O)2NR7a—, —N(R7a)S(O)2—, —OC(O)N(R7a)—, —N(R7a)C(O)NR7a—, —N(R7a)S(O)2N(R7a)—, or —OC(O)—;
• R7a is hydrogen or an optionally substituted C1-4 aliphatic, and
• R8 is an optionally substituted group selected from C1-6 aliphatic, 3-10-membered cycloaliphatic, 4-10-membered heterocyclyl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur,
• provided that:
• a) when CY is —CONHR4, then R2 is an optionally substituted group selected from 6-10-membered aryl, or 5-10-membered heteroaryl having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur.