Heteroaryl derivatives as CFTR modulators

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Ar1 is
• Ar1 is optionally substituted with w occurrences of —W—RW;
• wherein
• W is independently an optionally substituted (C1-C6) alkylidene chain wherein up to two methylene units of W are independently replaced by —CO—, —O—, —S—, —SO2—, or —NR′—;
• R′ is independently H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl;
• and
• RW is independently H, halo, CN, NO2, NH2, CF3, OCF3, OH, alkoxy, or an optionally substituted aliphatic, cycloaliphatic, heterocyclic, or heteroaryl, wherein, when substituted, RW is substituted with up to two R2;
• R2 is halo, CN, NO2, CF3, OCF3, OH, —(C1-C6)alkylidene-OH, —(C1-C6)alkylidene-N(R)2, OC(O)R, OC(O)N(R)2, SR, S(O)R, SO2R, SO2N(R)2, SO3R, C(O)R, CO2R, C(O)N(R)2, N(R)2, NRC(O)R, NRCO2R, NRC(O)N(R)2, NRSO2R, B(OR)2, or NRSO2N(R)2;
• R is independently H, alkyl, cycloalkyl, heterocyclic, aryl, or heteroaryl;
• RN is H, alkyl, aryl, heteroaryl, aralkyl, cycloalkyl, or heterocycloalkyl;
• A is an optionally substituted 3-7 membered monocyclic ring;
• B is optionally fused to a 5-7 membered ring selected from the group consisting of cycloaliphatic, aryl, heterocyclic, and heteroaryl;
• J is selected from the group consisting of CH2, CF2, C(CH3)2, C(O),
• C(Phenyl)2, B(OH), and CH(OEt);
• and
• w is independently an integer from 0 to 5 inclusive.