Pharmaceutical composition achieving excellent absorbency of pharmacologically active substance
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsYasuo Yamaguchi, Takakuni Matsuda, Yuso Tomohira
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Abstract
The present invention provides a pharmaceutical composition that can efficiently achieve its medicinal action by having excellent basic pharmacologically active substance absorbency, even the basic pharmacologically active substance is poorly soluble, the pharmaceutical composition being prepared by adding (i) a basic pharmacologically active substance together with (ii) a fatty acid and organic acid glycerol ester and/or fatty acid and organic acid polyglycerol ester.
Claims10
A pharmaceutical composition comprising:
- Component (i) a basic pharmacologically active substance comprising a 2,3-dihydroimidazo[2,1-b]oxazole compound represented by General Formula (I):
- wherein R1 is a hydrogen atom or a C1-C6 alkyl group;
- and R2-R6 are independently a hydrogen atom, or a halogen substituted or unsubstituted C1-C6 alkyl group, and
- Component (ii) a compound wherein one or two fatty acids and one or two organic acids are linked to a glycerol ester linkages, and/or a compound wherein one or two fatty acids and one or two organic acids are linked to a polyglycerol by ester linkages, wherein the organic acid of component (ii) is at least one member chosen from citric acid, acetic acid, lactic acid, succinic acid, tartaric acid, diacetyltartaric acid, malic acid, ascorbic acid, and fumaric acid.
A method for preparing a basic pharmacologically active substance-containing pharmaceutical composition comprising the step of combining:
- (i) a basic pharmacologically active substance comprising a 2,3-dihydroimidazo[2,1-b]oxazole compound represented by General Formula (I):
- wherein R1 is a hydrogen atom or a C1-C6 alkyl group;
- and R2-R6 are independently a hydrogen atom, or a halogen substituted or unsubstituted C1-C6 alkyl group;
- with
- (ii) a compound wherein one or two fatty acids and one or two organic acids are linked to a glycerol by ester linkages, and/or a compound wherein one or two fatty acids and one or two organic acids are linked to a polyglycerol by ester linkages, wherein the organic acid is at least one member chosen from citric acid, acetic acid, tactic acid, succinic acid, tartaric acid, diacetyltartaric acid, malic acid, ascorbic acid, and fumaric acid.
Dependencies are inferred from the claim text.