US 8,796,304 B2 · Tricyclic imidazole compounds as PDE10 inhibitors

Abstract

The invention is directed to compounds with the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

Claims11

Dependent claims

A compound having the structure I

wherein
X is selected from the group consisting of CH, CF, COCH3 and COH;
R1 and R2 are each selected independently from the group consisting of hydrogen;
C1-C6 alkyl;
C1-C6 alkyl(C3-C8)cycloalkyl;
C1-C6 hydroxyalkyl;
C1-C6 alkoxy;
CH2CN;
CH2C(O)NH2;
C1-C6 arylalkyl;
4-chlorobenzyl;
C1-C6 alkyl-heterocycloalkyl;
halogen;
and hydroxy;
L is a linker selected from the group consisting of —CH2—CH2—;
—CH═CH—;
—CH2—S—;
and —S—CH2—;
and
HET is a heteroaromatic group of formula II containing from 2 to 4 nitrogen atoms:
wherein
Y is N or CH;
Z is N or C;
and
HET optionally is substituted with up to three substituents R5, R6 and R7 individually selected from the group consisting of hydrogen;
C1-C6 alkyl;
halogen;
cyano;
halo(C1-C6)alkyl;
aryl;
C1-C6 alkoxy, and C1-C6 hydroxyalkyl;
and
“*” denotes the attachment point;
or a pharmaceutically acceptable acid addition salt thereof.

31 more elements

Dependencies are inferred from the claim text.

Tricyclic imidazole compounds as PDE10 inhibitors

Life of this patent

Tricyclic imidazole compounds as PDE10 inhibitors

Life of this patent

Abstract

Claims11