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US 8,796,303 B2Granted
Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections
AssigneeBiota Scientific Management Pty Ltd.
InventorsPenelope Anne Mayes, Jeffrey Peter Mitchell, Alistair George Draffan, Gary Robert William Pitt, Kelly Helen Anderson, Chin Yu Lim
Life of this patent
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Abstract
The present invention relates to compounds of formula (I), racemates, isomers and/or salts thereof useful in the treatment of viral infections, in particular respiratory syncytial virus (RSV) infections. The present invention also relates to processes for preparing the compounds.
Claims24
A compound of formula (I), racemates, stereoisomers and/or salts thereof:
- wherein
- X1 is N and X2 is CH;
- R1 is selected from a carbocyclic ring, a heterocyclic ring, an aromatic ring, a substituted carbocyclic ring, a substituted heterocyclic ring, and a substituted aromatic ring, wherein the substituent is one or more groups selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, aryl, halogen, halo C1-6alkyl, haloC2-6alkenyl, haloC2-6alkynyl, haloaryl, hydroxyl, C1-6alkylhydroxy, C1-6alkoxy, —OC1-6alkylhydroxy, —OC1-6alkylC1-6alkoxy, C2-6alkenyloxy, aryloxy, benzyloxy, haloC1-6alkoxy, haloC2-6alkenyloxy, haloaryloxy, nitro, nitroC1-6alkyl, nitroC2-6alkenyl, nitroC2-6alkynyl, nitroaryl, nitroheterocyclyl, amino, C1-6alkylamino, C1-6dialkylamino, C2-6alkenylamino, C2-6alkynylamino, arylamino, diarylamino, benzylamino, dibenzylamino, acyl, C2-6alkenylacyl, C2-6alkynylacyl, arylacyl, acylamino, diacylamino, acyloxy, alkylsulphonyloxy, arylsulphonyloxy, heterocyclyl, heterocyclyloxy, heterocyclylamino, haloheterocyclyl, alkylsulphonyl, arylsulphonyl, mercapto, C1-6alkylthio, benzylthio, and acylthio;
- R2 is selected from C1-6alkyl, haloC1-3alkyl and C1-3alkoxy;
- and
- R3 is H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, aryl, halogen, haloC1-6alkyl, haloC2-6alkenyl, haloC2-6alkynyl, haloaryl, hydroxy, C1-6alkylhydroxy, C1-6alkoxy, —OC1-6alkylhydroxy, —OC1-6alkylC1-6alkoxy, C2-6alkenyloxy, aryloxy, benzyloxy, haloC1-6alkoxy, haloC2-6alkenyloxy, haloaryloxy, nitro, nitroC1-6alkyl, nitroC1-6alkenyl, nitroC1-6alkynyl, nitroC2-6alkenyl, nitroC2-6alkynyl, nitroaryl, nitroheterocyclyl, amino, C1-6alkylamino, C1-6dialkylamino, C2-6alkenylamino, C2-6alkynylamino, arylamino, diarylamino, benzylamino, dibenzylamino, acyl, C2-6alkenylacyl, C2-6alkynylacyl, arylacyl, acylamino, diacylamino, acyloxy, alkylsulphonyloxy, arylsulphonyloxy, heterocyclyl, heterocyclyloxy, heterocyclylamino, haloheterocyclyl, alkylsulphonyl, arylsulphonyl, mercapto, C1-6alkylthio, benzylthio, or acylthio.
3 more elements
Dependencies are inferred from the claim text.