Aminopyrimidine derivatives as LRRK2 modulators

A compound of formula I:

• or pharmaceutically acceptable salts thereof,
• wherein:
• A is a five- or six-membered saturated or unsaturated ring that includes one or two heteroatoms selected from O, N and S, which is substituted once with R5, and which is optionally substituted one, two or three times with R6;
• X is:
• —NRa—;
• —O—;
• or —S(O)r— wherein r is from 0 to 2 and Ra is hydrogen or C1-6alkyl;
• R1 is:
• C1-6alkyl;
• C1-6alkenyl;
• C1-6alkynyl;
• halo-C1-6alkyl;
• C1-6alkoxy-C1-6alkyl;
• hydroxy-C1-6alkyl;
• amino-C1-6alkyl;
• C1-6alkylsulfonyl-C1-6alkyl;
• C3-6cycloalkyl optionally substituted with C1-6alkyl;
• C3-6cycloalkyl-C1-6alkyl wherein the C3-6cycloalkyl portion is optionally substituted with C1-6alkyl;
• tetrahydrofuranyl;
• tetrahydrofuranyl-C1-6alkyl;
• oxetanyl;
• or oxetan-C1-6alkyl;
• or R1 and Ra together with the atoms to which they are attached may form a three to six membered ring that may optionally include an additional heteroatom selected from O, N and S, and which is substituted with oxo, halo or C1-6alkyl;
• R2 is:
• halo;
• C1-6alkoxy;
• cyano;
• C1-6alkynyl;
• C1-6alkenyl;
• halo-C1-6alkyl;
• halo-C1-6alkoxy;
• C3-6cycloalkyl wherein the C3-6cycloalkyl portion is optionally substituted with C1-6alkyl;
• C3-6cycloalkyl-C1-6alkyl wherein the C3-6cycloalkyl portion is optionally substituted with C1-6alkyl;
• tetrahydrofuranyl;
• tetrahydrofuranyl-C1-6alkyl;
• acetyl;
• oxetanyl;
• or oxetan-C1-6alkyl;
• one of R3 and R4 is:
• halo;
• or C1-6alkoxy, and the other is hydrogen;
• R5 is;
• oxo;
• C1-6alkyl;
• C3-6cycloalkyl;
• C3-6cycloalkyl-C1-6alkyl;
• or —C(O)—NRbRc wherein Rb and Rc each independently is hydrogen or —C1-6alkyl, or Rb and Rc together with the atoms to which they are attached may form a heterocyclyl group that optionally includes an additional heteroatom selected from 0, N and S and which is optionally substituted one or more times with R6;
• and
• each R6 is independently:
• C1-6alkyl;
• C3-6cycloalkyl;
• C3-6cycloalkyl-C1-6alkyl;
• halo;
• halo-C1-6alkyl;
• hydroxy-C1-6alkyl;
• C1-6alkoxy-C1-6alkyl;
• heterocyclyl;
• oxo;
• or —C(O)—NRbRc.