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US 8,796,292 B2Granted
Selective antibacterials for clostridium difficile infections
AssigneeGLSynthesis Inc.
InventorsGeorge E. Wright, Wei-Chu Xu
Life of this patent
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Abstract
The invention features compounds of formula (I): The compounds are useful as antibacterial agents, especially again Clostridium difficile-associated diseases.
Claims13
A compound having the formula:
- wherein R1 and R2 are, independently, H, halo, C1-6 haloalkyl, or C1-6 haloalkoxy;
- wherein R3 is (CH2)m—B;
- in which B is H, substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C2-8 heterocyclyl or C1-10 heteroaryl, or OR12, in which R12 is substituted C1-6 alkyl, wherein the substituent is a heterocyclyl;
- and m is 1-3;
- or an optical isomer thereof, or a pharmaceutically acceptable salt thereof.
2 more elements
A method of inhibiting growth of Clostridium difficile in vitro, the method comprising contacting, in an appropriate culture medium in the absence of oxygen, Clostridium difficile with an effective amount of a compound having the formula:
- wherein R1 and R2 are, independently, H, halo, C1-6 haloalkyl, or C1-6 haloalkoxy;
- wherein R3 is (CH2)m—B;
- in which B is substituted or unsubstituted C3-8 cycloalkyl, substituted or unsubstituted C2-8 heterocyclyl or C1-10 heteroaryl, or OR12, in which R12 is substituted C1-6 alkyl, wherein the substituent is a heterocyclyl;
- and m is 1-3;
- or an optical isomer thereof, or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.