Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof

A compound having a general formula of:

• wherein said R, R1, R2 are selected from the group consisting of:
• (i) wherein said R is one of naphthalenyl and substituted naphthalenyl, said R1 is tri-halogenated alkyl, and said R2 is phenyl or substituted phenyl;
• (ii) wherein said R1 is halogenated alkyl, said R is thiophenyl and said R2 is one of phenyl and substituted phenyl;
• (iii) wherein said R1 is halogenated alkyl, said R is thiophenyl and said R2 is one of alkyl and substituted alkyl;
• (iv) wherein said R is one of naphthalenyl and substituted naphthalenyl, said R1 is tri-halogenated alkyl, and said R2 is one of phenyl and substituted phenyl;
• (v) wherein said R is thiophenyl, said R1 is selected from halogenated alkyl and alkylated halide, and said R2 is
• wherein X is one of O and NH, and n is a natural number selected from 0 to 6, wherein R3 is selected from the group consisting of:
• hydrogen, halogen, aryl, and substituted aryl;
• and
• (vi) wherein said R1 is halogenated alkyl, said R is thiophenyl and said R2 is one of pyridine and a substituted pyridine.

A compound having a general formula of:

• 2-trifluoromethyl-3-phenyl-5-chloromethylpyrazole[1,5-a]pyrimidin-7(4H)-one;
• 2-trifluoromethyl-3-phenyl-5-(2,6-dichloro-5-fluoropyrimidin-3-yl)pyrazole[1,5-a]pyrimidin-7(4H)-one;
• 2-trifluoromethyl-3-(naphthalen-1-yl)-5-chloromethylpyrazole[1,5]pyrimidin-7(4H)-one;
• 3-(naphthalen-1-yl)-2,5-bis(trifluoromethyl)pyrazole[1,5]pyrimidin-7(4H)-one;
• 2-trifluoromethyl-3-phenyl-5-(piperidin-1-ylmethyl)pyrazole pyrimindin-7(4H)-one;
• and
• N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydropyrazole[1,5-a]pyrimidin-5-yl)-2-(4-trifluoromethylphenyl)acetamide.