Radioprotector compounds and related methods
AssigneePeter MacCallum Cancer Institute
InventorsRoger Francis Martin, Jonathan Michael White
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Abstract
The invention relates to radioprotectors of formula (I), processes for their preparation and their use in protecting biological materials from radiation damage. In diagnostic and therapeutic radiology, particularly in cancer radiotherapy, the radioprotectors of the present invention may be used to protect certain normal tissues or structures from radiation damage. The radioprotectors of formula (I) may also have uses in decreasing the effects of irradiation in non-medical scenarios, both civil and military.
Claims9
A radioprotector compound of formula (I)
- wherein:
- X is alkylamino;
- Y and Z are N;
- R3 is N(R)2 or NHR, where R is C1 to C4 alkyl;
- R1, R2, R4 and R5 are selected from fluorine and hydrogen and at least one of R1, R2, R4 and R5 is F;
- and
- R6 to R11 are hydrogen.
A radioprotector compound of formula (I)
- wherein:
- X is alkylamino;
- Y and Z are N;
- R2 is N(R)2 or NHR, where R is C1 to C4 alkyl;
- R1, R3, R4 and R5 are selected from fluorine and hydrogen and at least one of R1, R3, R4 and R5 is F;
- and
- R6 to R11 are hydrogen.
A radioprotector compound of formula (I)
- wherein:
- X is alkylamino;
- Y and Z are N;
- R3 is N(R)2 or NHR, where R is C1 to C4 alkyl;
- R1 is fluorine;
- and
- R2 and R4 to R11 are hydrogen.
A radioprotector compound which is selected from:
Dependencies are inferred from the claim text.