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US 8,796,267 B2Granted
Oxazolidinone derivatives and methods of use
AssigneeConcert Pharmaceuticals, Inc.
InventorsRoger Tung, Scott Harbeson
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Abstract
This invention relates to novel N-[[3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide derivatives, their acceptable acid addition salts, solvates and hydrates. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antimicrobial agents.
Claims10
A compound of formula I or Ia:
- or a pharmaceutically acceptable salt thereof, wherein:
- each of W1, W2, W3, W4 and W5 is independently hydrogen or deuterium;
- each of Y1, Y2, Y3 and Y4 is independently hydrogen or deuterium;
- each of Z1, Z2, Z3 and Z4 is independently hydrogen, deuterium, or fluorine;
- and
- at least one of W1, W2, W3, W4, W5 is deuterium;
- at least two of Y1, Y2, Y3 and Y4 are deuterium;
- and
- at least two of Z1, Z2, Z3 and Z4 are deuterium or fluorine.
6 more elements
Dependencies are inferred from the claim text.