Fused heterocyclic derivatives as S1P modulators

A compound of the formula (I)

• or a pharmaceutically acceptable salt, solvate, or hydrate thereof, or an N-oxide of any of the foregoing,
• wherein
• R1 is selected from the group consisting of:
• a cyano group,
• a group independently selected from a (2-4C)alkenyl group, a (2-4C)alkynyl group, and a (1-4C)alkyl group, wherein each group is optionally substituted with a substituent independently selected from CN and at least one halogen atom,
• a group independently selected from a (3-6C)cycloalkyl group, a (4-6C)cycloalkenyl group, and a (8-10C)bicyclic group, wherein each group is optionally substituted with a substituent independently selected from a halogen atom and a (1-4C)alkyl group optionally substituted with at least one halogen atom, a group independently selected from a phenyl group, a biphenyl group, and a naphthyl group, wherein each group is optionally substituted with at least one substituent independently selected from halogen, cyano, (1-4C)alkyl optionally substituted with at least one halogen atom, (1-4C)alkoxy optionally substituted with at least one halogen atom, amino, dimethylamino, and (3-6C)cycloalkyl optionally substituted with a phenyl group wherein the phenyl group is optionally substituted with a substituent independently selected from (1-4C)alkyl and a halogen atom, and
• a phenyl group substituted with a group selected from the group consisting of a phenoxy group, a benzyl group, a benzyloxy group, a phenylethyl group, and a monocyclic heterocycle group, wherein each group is optionally substituted with (1-4C)alkyl,
• Z is a —W—(Cn-alkylene)-T-group wherein
• W is attached to R1 and selected from the group consisting of a bond, —O—, —CO—, —S—, —SO—, —SO2—, —NH—, —CH═CH—, —C(CF3)═CH—, —C≡C—, —CH2—O—, —O—CO—, —CO—O—, —CO—NH—, NH—CO— and a trans-cyclopropylene;
• n is an integer from 0 to 10;
• and
• T is attached to the phenylene/pyridyl moiety and selected from the group consisting of a bond, —O—, —S—, —SO—, —SO2—, —NH—, —CO—, —C═C—, —C≡C—, and a trans-cyclopropylene;
• R2 is selected from the group consisting of H and at least one substituent independently selected from cyano, halogen, (1-4C)alkyl optionally substituted with at least one halogen atom, and (1-4C)alkoxy optionally substituted with at least one or more halogen atom;
• ring structure A optionally contains a nitrogen atom;
• X is selected from the group consisting of C and N;
• wherein if X is C, R3 is selected from H and (1-4C)alkyl, and if X is N, R3 is not present;
• Y is selected from the group consisting of NH, O and S;
• structure Q is selected from the group consisting of a 5-, 6- and 7-membered cyclic amine;
• and
• R4 is selected from
• a (1-4C)alkylene-R5 group wherein at least one carbon atom in the alkylene group may independently be substituted with a substituent selected from at least one halogen atom and a (CH2)2 to form a cyclopropyl moiety, or
• a group independently selected from (3-6C)cycloalkylene-R5, —CH2-(3-6C)cycloalkylene-R5, (3-6C)cycloalkylene-CH2—R5 and —CO—CH2—R5, wherein R5 is selected from —OH, —PO3H2, —OPO3H2, —COOH, —COO(1-4C)alkyl and tetrazol-5yl.