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US 8,796,255 B2Granted
Mutant-selective EGFR inhibitors and uses thereof
AssigneeCelgene Avilomics Research, Inc.
InventorsKwangho Lee, Deqiang Niu, Matthew F. Baevsky
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Abstract
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
Claims9
A compound of formula I:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is —CF3 or —Cl;
- W is —O— or —NH—;
- R2 is —R or
- R3 is —R, —C(O)R, or —C(O)OR;
- and
- each R is independently C1-4 alkyl or C1-4 fluoroalkyl.
4 more elements
A compound of formula II:
- or a pharmaceutically acceptable salt thereof, wherein:
- R3 is —R, —C(O)R, or —C(O)OR;
- and
- each R is independently C1-4 alkyl or C1-4 fluoroalkyl.
1 more element
Dependencies are inferred from the claim text.