Heteroaryl substituted pyrazole derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis

A compound having the formula:

• or a physiologically acceptable salt thereof, wherein:
• A is heteroaryl optionally substituted with halogen or phenyl, or is heterocyclyl;
• n is an integer from 0-3;
• R1 at each occurrence is independently halogen, —NR6C(O)R7, —C(O)R6, —C(O)OR6, —OC(O)R6, —OR6, —SR6, —S(O)R6, —SO2R6, cyano, nitro, —C(O)NR6R7, —SO2NR6R7, or —NR6R7,
• or
• R1 is independently aryl, heteroaryl, heterocyclyl, alkyl or cycloalkyl each optionally substituted with one or more halogen, OR6 or NR6R7 groups;
• R2 is aryl optionally substituted with 1, 2 or 3 R8 groups or heteroaryl optionally substituted with 1, 2 or 3 R8 groups, when A is mono- or bicyclic heteroaryl or mono- or bicyclic heterocyclyl,
• or
• R2 is hydrogen, halogen, cyano, alkyl optionally substituted with up to 3 fluoro atoms, alkyloxy optionally substituted with up to 3 fluoro atoms, cycloalkyl, aryloxy, aroyl, aralkyl optionally substituted with halogen, or heterocyclyl optionally substituted with alkyl, when A is bi- or tricyclic heteroaryl or mono-, bi- or tricyclic heterocyclyl;
• R3 and R4 are each independently hydrogen, halogen, —OR6, —SR6, —NR6R7, alkyl optionally substituted with one or more halogen, R6, —OR6 or —NR6R7 groups, or cycloalkyl optionally substituted with one or more halogen, R6, —OR6 or —NR6R7 groups;
• R5 is hydrogen, oxo, or alkyl optionally substituted with one or more halogen, —OR6 or —NR6R7 groups;
• each occurrence of R6 or R7 may be the same or different and is independently hydrogen, or aryl, heteroaryl, heterocyclyl, alkyl, or cycloalkyl each of which may be optionally substituted with one or more hydrogen, halogen, —OR9 or —NR9R10 groups;
• each occurrence of R8 may be the same or different and is independently
• hydrogen, halogen, —NR9C(O)R10, —NR9C(O)OR10, —C(O)R9, —C(O)OR9, —OC(O)R9, —OR9, —SR9, —S(O)R9, —SO2R9, cyano, nitro, —C(O)NR9R10, —SO2NR9R10, —NR9R10, or
• aryl, heteroaryl, heterocyclyl, alkyl, or cycloalkyl, each of which may be optionally substituted with one or more halogen, R11, —OR9 or —NR9R10 groups;
• each occurrence of R9 and R10 may be the same or different and is independently hydrogen, or aryl, heteroaryl, heterocyclyl, alkyl, cycloalkyl, aralkyl, or heterocyclylalkyl each of which may be optionally substituted with one or more hydrogen, halogen, hydroxyl, alkyloxy, cycloalkyloxy, aryloxy, amino, alkylamino, cycloalkylamino, arylamino, alkyl, cycloalkyl, alkylcarbonyl or alkoxycarbonyl groups;
• each occurrence of R11 may be the same or different and is independently hydrogen, oxo, aryl, heteroaryl, heterocyclyl, alkyl, cycloalkyl, —C(O)R9, —C(O)OR9, —NR12C(O)R13, —N[C(O)R13]2, —NR12C(O)OR13, or —N[C(O)OR13]2;
• R12 is hydrogen or alkyl;
• and
• R13 is alkyl.