Oligomer-corticosteroid conjugates
AssigneeNektar Therapeutics
InventorsWen Zhang, Jennifer Riggs-Sauthier, J. Milton Harris, Michael D. Bentley
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Abstract
The invention provides corticosteroids that are chemically modified by covalent attachment of a water soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water soluble oligomer.
Claims10
A compound comprising a corticosteroid residue covalently attached via a releasable linkage to a water-soluble, non-peptidic oligomer, wherein the compound is selected from a compound of the formula:
- wherein POLY is a water-soluble, non peptidic oligomer having a number of repeating monomers in the range of from 2 to 30.
Dependencies are inferred from the claim text.