Indole derivative, and pharmacologically acceptable salt thereof

A compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof:

• wherein A represents a group selected from the group consisting of the following a) to h):
• one of W1 and W2 represents a nitrogen atom and the other represents ═CH— or a nitrogen atom;
• W3 represents an oxygen atom or a sulfur atom;
• W4 represents ═CH— or a nitrogen atom;
• X represents a hydrogen atom or a halogen atom;
• Y1 represents a C1-6 alkylene group;
• Y2 represents a single bond or an oxy-C1-6 alkylene group;
• R1 represents a group selected from the group consisting of the following i) to n):
• i) —C(═O)—NH—SO2—R6,
• j) —C(═O)—NH—OH,
• k) —C(═O)—NH—CN,
• l) —NH—C(═O)—R6,
• m) an acidic 5-membered hetero ring group, and
• n) a 6-membered aromatic ring group substituted with a phenolic hydroxy group;
• R2 represents a group selected from the group consisting of the following o) to t):
• o) a branched C3-6 alkyl group,
• p) a halo-C1-6 alkyl group,
• q) a C3-6 cycloalkyl group, in which the ring is unsubstituted or substituted with one C1-6 alkyl group,
• r) a phenyl group, in which the ring is unsubstituted or substituted with one to five groups independently selected from the group consisting of the following:
• a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, a hydroxy-C1-6 alkyl group, a C1-6 alkoxy group, and a cyano group,
• s) a 6-membered aromatic heterocyclic group, in which the ring is unsubstituted or substituted with one to four groups independently selected from the group consisting of the following:
• a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, a hydroxy-C1-6 alkyl group, a C1-6 alkoxy group, and a cyano group, and
• t) a 5-membered aromatic heterocyclic group, in which the ring is unsubstituted or substituted with one to three groups independently selected from the group consisting of the following:
• a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, a hydroxy-C1-6 alkyl group, a C1-6 alkoxy group, and a cyano group;
• R3 represents a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, a hydroxy-C1-6 alkyl group, a C1-6 alkoxy group, a halo-C1-6 alkoxy group, a C1-6 alkylsulfanyl group, a C3-6 cycloalkyl group, a cyano group, an amino group, or a nitro group;
• R4 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group;
• R5 represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group;
• R6 represents a group selected from the group consisting of the following u) to x):
• u) a C1-6 alkyl group,
• v) a halo-C1-6 alkyl group,
• w) a C3-6 cycloalkyl group, and
• x) a phenyl group, in which the ring is unsubstituted or substituted with one to five groups independently selected from the group consisting of the following:
• a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, and a C1-6 alkoxy group (with the proviso that the bonds with (*) represent binding to Y1;
• and the bonds with (**) represent binding to Y2).