Methods and compositions for regenerating articular cartilage
AssigneeGenera Istrazivanja d.o.o.
InventorsSlobodan Vukicevic, Mislav Jelic
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Abstract
Methods and compositions are described to regenerate cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising an infiltration suppressor agent and a columnar growth promoting agent.
Claims15
A composition adapted for regenerating articular cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising:
- an infiltration suppressor agent that suppresses or inhibits infiltration of synoviocytes, fibroblasts, or subchondral bone marrow cells into a partial thickness defect or area of reduced volume of articular cartilage, wherein the infiltration suppressor agent is dexamethasone or a combination of dexamethasone and a cartilage-derived morphogenetic protein (CDMP);
- and
- a columnar growth promoting agent that promotes columnar growth of articular chondrocytes in a partial thickness defect or area of reduced volume of articular cartilage, wherein the columnar growth promoting agent is an osteoinductive bone morphogenetic protein (BMP);
- and wherein TGF-β is not present in said composition.
A kit composition for regenerating articular cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising:
- an infiltration suppressor agent that suppresses or inhibits infiltration of synoviocytes, fibroblasts, or subchondral bone marrow cells into a partial thickness defect or area of reduced volume of articular cartilage, wherein the infiltration suppressor agent is dexamethasone or a combination of dexamethasone and a cartilage-derived morphogenetic protein (CDMP);
- a columnar growth promoting agent that promotes columnar growth of articular chondrocytes in a partial thickness defect or area of reduced volume of articular cartilage, wherein the columnar growth promoting agent is an osteoinductive bone morphogenetic protein (BMP);
- and
- instructions for administering the infiltration suppressor agent prior to or simultaneously with administering the columnar growth promoting agent to the partial thickness defect or area of reduced volume of articular cartilage
- and wherein TGF-β is not present in said kit composition.
A composition adapted for regenerating articular cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising:
- an infiltration suppressor agent that suppresses or inhibits infiltration of synoviocytes, fibroblasts, or subchondral bone marrow cells into a partial thickness defect or area of reduced volume of articular cartilage, wherein the infiltration suppressor agent is a combination of dexamethasone and CDMP-2;
- and
- a columnar growth promoting agent that promotes columnar growth of articular chondrocytes in a partial thickness defect or area of reduced volume of articular cartilage, wherein the columnar growth promoting agent is BMP-7 or BMP-4.
A kit composition for regenerating articular cartilage in a partial thickness defect or area of reduced volume of articular cartilage comprising:
- an infiltration suppressor agent that suppresses or inhibits infiltration of synoviocytes, fibroblasts, or subchondral bone marrow cells into a partial thickness defect or area of reduced volume of articular cartilage, wherein the infiltration suppressor agent is a combination of dexamethasone and a cartilage-derived morphogenetic protein-2 (CDMP-2);
- a columnar growth promoting agent that promotes columnar growth of articular chondrocytes in a partial thickness defect or area of reduced volume of articular cartilage, wherein the columnar growth promoting agent is BMP-7 or BMP-4;
- and
- instructions for administering said infiltration suppressor agent prior to or simultaneously with administering said columnar growth promoting agent to the partial thickness defect or area of reduced volume of articular cartilage.
Dependencies are inferred from the claim text.