Aqueous formulation of erythropoiesis stimulating protein stabilised by antioxidants for parenteral administration

An aqueous formulation suitable for parenteral administration comprising an erythropoiesis stimulating protein, wherein the erythropoiesis stimulating protein is a protein that is 90% or more identical in amino acid sequence to human erythropoietin (SEQ ID NO:

• 1) or darbepoetin (SEQ ID NO:
• 2), and a stabilizing concentration of an antioxidant, wherein the antioxidant is selected from the group consisting of furaneol and sulisobenzone, and wherein,
• when the antioxidant is furaneol, the antioxidant is present in the aqueous formulation at a concentration of about 0.1 mM to about 300 mM and
• when the antioxidant comprises sulisobenzone, the antioxidant is present in the aqueous formulation at a concentration of about 0.1 mM to about 300 mM.