Use of tight junction antagonists to treat inflammatory bowel disease
AssigneeAlba Therapeutics Corporation
InventorsBlake Paterson, Amir Tamiz, Niranjan Pandey
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Abstract
The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents.
Claims14
A method for treating Inflammatory Bowel Disease (IBD) in a patient, the method comprising:
- administering a peptide having the amino acid sequence GGVLVQPG (SEQ ID NO:15) to the colon of a patient having IBD.
A method for treating chronic Inflammatory Bowel Disease (IBD) in a patient in need thereof, the method comprising:
- administering to the patient one or more times per day for a plurality of days, a peptide having the amino acid sequence GGVLVQPG (SEQ ID NO:15), the peptide being administered in a delayed release composition to the colon of the subject.
Dependencies are inferred from the claim text.