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US 8,796,201 B2Granted
Enzyme treatment of foodstuffs for celiac sprue
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsLu Shan, Michael Bethune, Chaitan Khosla, Jonathan Gass, Gail G. Pyle, Gary M. Gray, Indu Isaacs, Gregg Strohmeier
Life of this patent
Estimating the term…
Abstract
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.
Claims17
A formulation for use in treatment of Celiac Sprue and/or dermatitis herpetiformis, comprising:
- an effective dose of two glutenases and a pharmaceutically acceptable excipient wherein said effective dose of two glutenases is formulated in two enzyme doses, one dose containing a prolyl endopeptidase (PEP), and the other dose containing Hordeum vulgare endoprotease.
A method of treating Celiac Sprue and/or dermatitis herpetiformis, the method comprising:
- administering to a patient an effective dose of a two glutenases;
- wherein said effective dose of two glutenases attenuates gluten toxicity in said patient and is administered in two enzyme doses, one dose containing a prolyl endopeptidase (PEP), and the other dose containing Hordeum vulgare endoprotease.
Dependencies are inferred from the claim text.