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US 8,796,185 B2Granted
Self-assembling high density ordered patterned biomolecule array and method for making and using the same
AssigneeLightSpeed Genomics, Inc.
InventorsDae Hyun Kim, Sungjoon Kim
Life of this patent
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Abstract
A method for fabricating a universal substrate for attaching biomolecules, including sequencing features and the resulting substrate. A method of direct detection of analytes utilizes a Complementary Metal Oxide Semiconductor (CMOS) sensor with the substrate.
Claims18
A patterned substrate comprising a substrate comprising a plurality of first regions and a second region wherein:
- the plurality of first regions have a density on the substrate between 5×106 and 25×106/mm2 and an associated biomolecule specifically located at each of said plurality of first regions and a complementary metal-oxide semiconductor (CMOS) sensor specifically located at each of said plurality of first regions.
A method for building a patterned substrate comprising:
- providing a substrate comprising a plurality of complementary metal oxide semiconductor (CMOS) sensors at a density of between 5×106 and 25×106/mm2;
- etching a well onto the substrate at each CMOS sensor;
- coating the plurality of wells with a first coating;
- and
- associating a biomolecule to each of the plurality of wells.
2 more elements
Dependencies are inferred from the claim text.