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US 8,796,027 B2Granted
Nucleic acid complex and method of introducing nucleic acid into cell using the same
AssigneesJnc Corporation, Takeshi Nagasaki
InventorsTakeshi Nagasaki, Seiji Shinkai, Atsushi Uno, Mamoru Nishida
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Abstract
A nucleic acid is effectively introduced into a cell while suppressing the cytotoxicity by administering a nucleic acid complex comprising a high molecular weight derivative of ε-poly-L-lysine and a nucleic acid to a cell.
Claims3
A nucleic acid complex, comprising a high molecular weight derivative of ε-poly-L-lysine and a plasmid DNA,
- wherein the high molecular weight derivative of ε-poly-L-lysine is obtained by dehydration-condensation of ε-poly-L-lysine subunits of Formula (I),
- and wherein the high molecular weight derivative of ε-poly-L-lysine has a molecular weight of 10,000 to 50,000 Da.
Dependencies are inferred from the claim text.