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US 8,796,022 B2Granted
Generation of functional basal forebrain cholinergic neurons from stem cells
AssigneeNorthwestern University
InventorsChristopher Bissonnette, John Kessler
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Abstract
The present invention provides method, compositions, and systems for generating basal forebrain cholinergic neurons (BFCNs) using FGF8, SHH, LXH8, GBX1, or vectors encoding these ligands, as well as using such BFCNs to treat neurological disorders such as Alzheimer's disease.
Claims6
A method of generating basal forebrain cholinergic neurons (BFCNs) in vitro comprising:
- treating isolated neural progenitor cells with:
- i) an effective amount of FGF8, or a biologically active fragment or variant thereof, and ii) an effective amount of Sonic Hedgehog (SHH) or a biologically active fragment or variant thereof, wherein said treating generates BFCNs.
Dependencies are inferred from the claim text.