Back to results
US 8,796,018 B2Granted
Use of nanopatterned surfaces and method for enriching or isolating cellular subpopulations
AssigneeLeibniz-Institut fuer Neue Materialien Gemeinneutzige Gesellschaft mit beschraenkter Haftung
InventorsMichael Veith, Frank Narz
Life of this patent
Estimating the term…
Abstract
The invention relates to the use of nanopatterned surfaces. It also relates to a method for enriching or isolating cellular subpopulations. To create a simple, versatile and specific method for enriching or isolating cellular subpopulations from a complex mixture, the invention proposes the use of nanopatterned surfaces for isolating and enriching cellular subpopulations from a complex mixture.
Claims4
A method for enriching or isolating Jurkat cells from a complex mixture of cellular subpopulations, the method comprising a step of:
- enriching the cellular subpopulations cyclically by detaching cells alive and cultivating and further processing them on nanopatterned surfaces, said cellular subpopulations being intrinsically non-adherent cells and said nanopatterned surfaces being made up of one-dimensional nanowires comprising a metallic core surrounded by a ceramic shell, have two dimensions in the sub-micrometer range and are produced by thermolytic decomposition of compounds having the general formula El(OR)H2, where El stands for the elements Al, Ga, In and Ti and R for an alkyl (C3-C10) or a cycloalkyl (C5-C8) group.
Dependencies are inferred from the claim text.