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AssigneesBoard of Regents, The University of Texas System, Rutgers, The State University of New Jersey
InventorsGaetano Montelione, Kalyan Das, Edward Arnold, Li-Chung Ma, Rong Xiao, Rei-Lin Kuo, Robert M. Krug, Karen Y. Twu
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The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.
A process for engineering a live attenuated influenza A virus vaccine by mutation of specific residues in the CPSF30-binding site of the NS1A protein, a tetramer interface and combinations thereof, based on the 3D structure of the complex formed between NS1A (85-215) and F2F3.
Dependencies are inferred from the claim text.