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US 8,796,001 B2Granted
Metalloenzyme inhibitor compounds
AssigneeViamet Pharmaceuticals, Inc.
InventorsWilliam J. Hoekstra, Christopher M. Yates, Robert J. Schotzinger, Michael R. Loso, Zachary A. Buchan, Michael T. Sullenberger
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Abstract
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
Claims22
A compound of Formula I, or salt thereof, wherein:
- MBG is optionally substituted tetrazoly, optionally substituted triazolyl, optionally substituted oxazolyl, optionally substituted pyrimidinyl, optionally substituted thiazolyl, or optionally substituted pyrazolyl;
- R1 is H, halo, alkyl or haloalkyl;
- R2 is H, halo, alkyl or haloalkyl;
- R3 is independently H, alkyl, nitro, cyano, haloalkyl, alkoxy, halo, haloalkoxy, alkenyl, haloalkenyl, cycloalkyl, halocycloalkyl, alkynyl, haloalkynyl, thioalkyl, SF3, SF6, SCN, SO2R6, —C(O)-alkyl, —C(O)OH, —C(O)O-alkyl, C(O)H, CH═N—O-alkyl, —CH═N—O-arylalkyl;
- R4 is aryl, heteroaryl or cycloalkyl optionally substituted with 0, 1, 2 or 3 independent R3;
- R5 is alkyl, haloalkyl, cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl, each optionally substituted with 0, 1, 2 or 3 independent R3;
- R6 is alkyl, aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- R7 is H, alkyl, —Si(R8)3, —P(O)(OH)2, —CH2—O—P(O)(OH)2, or —C(O)-alkyl optionally substituted with amino;
- R8 is independently alkyl or aryl;
- R9 is independently H, alkyl, halo, or haloalkyl;
- and
- X is O or S.
9 more elements
Dependencies are inferred from the claim text.