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US 8,795,974 B2Granted
Anti-LG3 antibodies and uses thereof
AssigneeVal-Chum, Limited Partnership
InventorsMarie-Josee Hebert, Heloise Cardinal, Nathalie Brassard
Life of this patent
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Abstract
A method for the prediction of the risk and/or the diagnosis of vascular damage such as acute vascular rejection in a subject, based on the determination of anti-LG3 antibodies levels in a sample from the subject, is disclosed.
Claims19
A method for treating vascular damage in a human subject in need thereof, said method comprising:
- (i) identifying a human subject suffering from vascular damage by:
- (a) measuring a level of antibodies directed against LG3 (anti-LG3) in a biological sample from said subject;
- (b) comparing said level to a control level;
- (c) identifying a subject suffering from vascular damage based on said comparison, wherein a higher level of anti-LG3 in said sample relative to said control level is indicative that said subject suffers from vascular damage;
- and
- (ii) providing a suitable therapy against vascular damage to said subject suffering from vascular damage.
3 more elements
A method for treating acute vascular rejection (AVR) in a candidate human solid organ transplant recipient at risk thereof, said method comprising:
- (i) identifying a candidate human solid organ transplant recipient at risk of suffering from AVR by:
- (a) measuring a level of antibodies directed against LG3(anti-LG3) in a biological sample from said candidate solid organ transplant recipient;
- (b) comparing said level to a control level;
- (c) identifying a candidate solid organ transplant recipient at risk of suffering from AVR based on said comparison, wherein a higher level of anti-LG3 in said sample relative to said control level is indicative that said subject is at risk of suffering from AVR;
- and
- (ii) providing a suitable anti-rejection therapy to said subject at risk of suffering from AVR.
3 more elements
An assay mixtures comprising (i) a recombinant human LG3 polypeptide;
- and
- (ii) a biological sample from a human solid organ transplant recipient.
Dependencies are inferred from the claim text.