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US 8,795,963 B2Granted
Genetic markers for risk management of atrial fibrillation and stroke
AssigneedeCODE Genetics ehf.
InventorsHilma Holm, Daniel Gudbjartsson
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Abstract
The invention relates to procedures and methods of determining a susceptibility to cardiac arrhythmia, including Atrial Fibrillation, Atrial Flutter and Stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with risk of these conditions. The invention further relates to kits encompassing reagents for assessing such markers, and diagnostic methods, uses and procedures for utilizing such susceptibility markers.
Claims27
A method for determining a susceptibility to a condition selected from the group consisting of:
- cardiac arrhythmia selected from Atrial Fibrillation and Atrial Flutter, and Stroke, in a human individual, the method comprising:
- analyzing nucleic acid from a biological sample from the human individual for a T allele of a polymorphic marker rs7193343;
- detecting a T allele of rs7193343 in the nucleic acid;
- determining that the individual has an increased genetic susceptibility to a condition selected from the group consisting of:
- cardiac arrhythmia selected from Atrial Fibrillation and Atrial Flutter, and Stroke from the detection of the T allele of rs7193343 in the nucleic acid;
- and
- performing an electrocardiogram or initiating anticoagulant therapy on the individual determined to have the increased susceptibility to the condition.
4 more elements
Dependencies are inferred from the claim text.