Interferometric spectral imaging of a two-dimensional array of samples using surface plasmon resonance
AssigneeGeneral Electric Company
InventorsAbhijit Vishwas Patil, Sandip Maity, Veera Venkata Lakshmi Rajesh Langoju, Anusha Rammohan, Sameer Dinkar Vartak, Umakant Damodar Rapol
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Abstract
A detection system for a two-dimensional (2D) array is provided. The detection system comprises an electromagnetic radiation source, a phase difference generator, a detection surface having a plurality of sample fields that can receive samples, and an imaging spectrometer configured to discriminate between two or more spatially separated points.
Claims20
A detection system for interferometric spectral imaging of a two-dimensional (2D) array of samples, comprising:
- a broadband light source;
- a detection surface having a plurality of sample fields configured to receive a two-dimensional array of samples, wherein one or more portions of the detection surface comprise a metal film having gold, and wherein the broadband light source is configured to provide light to the detection surface at an incidence angle configured to produce a surface plasmon resonance phenomenon;
- a phase difference generator configured to resolve the sample fields of the plurality of sample fields, wherein the phase difference generator is configured to generate a phase difference in a reference beam or a resultant sample beam by introducing a path length difference between the resultant sample beam and the reference beam;
- an interferometer configured to combine the reference beam and the resultant sample beam;
- and
- an imaging spectrometer comprising a spectrally separated two-dimensional detector configured to receive the combined reference and resultant sample beams, and wherein the imaging spectrometer is configured to discriminate between two or more spatially separated points in the two-dimensional array of samples based on the combined reference and resultant sample beams.
A two-dimensional surface plasmon resonance imaging system, comprising:
- a surface plasmon resonance surface having a two-dimensional array of samples disposed in one or more corresponding sample fields;
- a broadband light source that illuminates one or more of the sample fields;
- a phase difference generator that introduces differences in pathlengths of resultant sample beams reflected from the two-dimensional array of samples;
- and
- a detector that receives the resultant sample beams from the two-dimensional array of samples.
A method for simultaneous imaging of samples in a two-dimensional array of samples, comprising:
- providing a sample beam and a reference beam using a broadband light source, wherein the sample beam is provided at an incidence angle configured to produce a surface plasmon resonance phenomenon;
- illuminating the samples in the two-dimensional array of samples with the sample beam to produce a resultant sample beam, wherein the samples in the two-dimensional array of samples are disposed on a detection surface comprising a thin metal film;
- introducing a path length difference in one of the reference beam or the resultant sample beam;
- interfering the resultant sample beam with the reference beam to form interference spectra;
- spectrally separately acquiring the interference spectra;
- and
- reconstructing an image of the two-dimensional array of samples using a Fourier transform of the acquired interference spectra.
Dependencies are inferred from the claim text.