Canine thymic stromal lymphopoietin protein and uses thereof to treat allergic symptoms
AssigneeIntervet Inc.
InventorsJeanine D. Mattson, Daniel M. Gorman, Rene de Waal Malefyt, Mohamad A. Morsey
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Abstract
The present invention discloses a canine TSLP protein and a nucleic acid that encodes that protein. Peptide fragments of the protein that comprise specific epitopes of the canine TSLP protein are also disclosed. The canine TSLP protein and related peptide fragments may be used as an antigen for immunological assays, as well as for vaccines that induce anti-TSLP antibodies. The present invention further discloses methods of making and using the canine TSLP gene, the canine TSLP protein, and the related peptide fragments.
Claims12
An isolated anti-canine thymic stromal lymphopoietin protein (TSLP) antibody elicited in a mammal or in a mammalian hybridoma system with a composition comprising a TSLP or an antigenic fragment thereof, wherein said TSLP comprises an amino acid sequence that has 90% or greater identity to the amino acid sequence of SEQ ID NO:
- 2, excluding the 28 amino acid residue signal sequence.
An isolated anti-canine thymic stromal lymphopoietin protein (TSLP) antibody elicited in a mammal or in a mammalian hybridoma system, obtained with a composition comprising a fusion protein;
- wherein said fusion protein comprises a thymic stromal lymphopoietin protein (TSLP) or an antigenic fragment thereof;
- and
- wherein said TSLP comprises an amino acid sequence that has 90% or greater identity to the amino acid sequence of SEQ ID NO:
- 2, excluding the 28 amino acid residue signal sequence.
Dependencies are inferred from the claim text.