Compositions and methods for treatment of non-hodgkins lymphoma
AssigneeThe Trustees of the University of Pennsylvania
InventorsYvonne Paterson, Paul Neeson
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Abstract
The present invention provides recombinant peptides comprising a B cell receptor (BCR) or a fragment thereof, nucleotide molecules encoding same, and vaccines and vectors comprising same; and methods of treating, inducing an immune response against, inducing a regression of, and suppressing a formation of a lymphoma, comprising administering same. The present invention also provides methods of inducing a humoral immune response in an animal against an antigen, comprising administering to the animal a fusion peptide comprising an LLO protein or fragment thereof fused to the antigen.
Claims12
A fusion peptide comprising a listeriolysin O (LLO) protein or a fragment thereof and an antigen, wherein said LLO protein or fragment thereof is chemically conjugated to said antigen, wherein said chemical conjugation to said antigen enables both a cell-mediated response and a humoral response to said antigen, wherein said antigen is a fragment of a B cell receptor (BCR), and wherein said fragment comprises the idiotype of said BCR.
An isolated peptide vaccine mixture, comprising an LLO protein or fragment thereof, and an antigen, wherein said antigen is either
- a. a B cell receptor (BCR);
- or
- b. a fragment of a BCR, wherein said fragment comprises the idiotype of said BCR.
Dependencies are inferred from the claim text.