Aryl dihydropyridinone and piperidinone MGAT2 inhibitors

A compound of Formula (I):

• or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
• designates a single or double bond;
• x and y can be both a single bond;
• when x is a double bond, then y is a single bond and R4 and R16 are absent;
• when y is a double bond, then x is a single bond and R5 and R16 are absent;
• R1 is independently selected from the group consisting of:
• —CONH(C4-18 alkyl), —CONHC2-8 haloalkyl, —CONH(CH2)1-8Ph, —CONHCH2COC2-8 alkyl, —(CH2)m—(C3-10 carbocycle substituted with 0-2 Rb and 0-2 Rg), —(CH2)m-(5- to 6-membered heteroaryl comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O and S;
• wherein said heteroaryl is substituted with 0-1 Rb and 0-2 Rg), and a C1-12 hydrocarbon chain substituted with 0-3 Ra;
• wherein said hydrocarbon chain may be straight or branched, saturated or unsaturated;
• R2 is independently selected from the group consisting of:
• C1-4 alkyl, C3-4 cycloalkyl, and C1-4 haloalkyl;
• R3 is independently selected from the group consisting of:
• H, F, Cl, C1-4 alkyl and CN;
• R4 and R5 are independently selected from the group consisting of:
• H, F, Cl, and C1-4 alkyl;
• when x is a single bond, R3 and R4 may be combined with the carbon atom to which they are attached to form a 3- to 6-membered carbocycle;
• R6 is independently selected from the group consisting of:
• H, halo, C1-4 alkyl, NO2, Rc, —(CH2)n—(X)t—(CH2)mRc, NH2, —CONH(C1-6 alkyl), —NHCOX1SO2Rj, —NHCOCH2PO(OEt)2, —NHCOCORj, —NHCOCH(OH)Rj, —NHCOCH2CORj, —NHCONHRj, and —OCONRfRj;
• X is independently selected from the group consisting of:
• O, S, NH, CONH, and NHCO;
• X1 is independently C1-4 hydrocarbon chain optionally substituted with C1-4 alkyl or C3-4 cycloalkyl;
• when y is a single bond, R5 and R6 may be combined with the carbon atom to which they are attached to form a 3- to 6-membered carbocycle;
• R11, R12, R13, R14 and R15 are independently selected from the group consisting of:
• H, halo, C1-4 alkyl substituted with 0-2 Ri, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, —(CH2)m—C3-6 cycloalkyl, CN, NRfRj, ORj, SRj, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), and a 4- to 6-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S;
• alternatively, R11 and R12, together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered heterocyclic ring comprising:
• carbon atoms and 1-3 heteroatoms selected from N, NRe, O, and S;
• alternatively, R12 and R13, together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered heterocyclic ring comprising:
• carbon atoms and 1-3 heteroatoms selected from N, NRe, O, and S;
• R16 is independently selected from the group consisting of:
• H and C1-4 alkyl;
• Ra is, at each occurrence, independently selected from the group consisting of:
• halo, OH, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, N(C1-4 alkyl)2, —(CH2)n(X)t—(CH2)mRc, and —(CH2)n—(CH2O)m—(CH2)nRf;
• Rb is, at each occurrence, independently selected from the group consisting of:
• halo, OH, C1-10 alkyl, C1-10 alkoxy, C1-10 haloalkyl, C1-10 haloalkoxy, C1-10 alkylthio, C1-10 haloalkylthio, N(C1-4 alkyl)2, —CONH(CH2)4-20H, —O(CH2)sO(C1-6 alkyl), Rc, —(CH2)n—(X)t—(CH2)mRc, and —(CH2)n—(CH2O)m—(CH2)nRf;
• Rc is, at each occurrence, independently selected from the group consisting of:
• C3-6 cycloalkyl substituted with 0-2 Rd, C3-6 cycloalkenyl substituted with 0-2 Rd, —(CH2)m-(phenyl substituted with 0-3 Rd), and a 5- to 6-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S;
• wherein said heterocycle is substituted with 0-2 Rd;
• Rd is, at each occurrence, independently selected from the group consisting of:
• halo, OH, CN, NO2, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, tetrazolyl, OBn and phenyl substituted with 0-2 Rh;
• Re is, at each occurrence, independently selected from the group consisting of:
• H, C1-8 alkyl, C1-8 haloalkyl, benzyl optionally substituted with C1-4 alkoxy, CO(C1-4 alkyl) and COBn;
• Rf is, at each occurrence, independently selected from the group consisting of:
• H and C1-4 alkyl;
• Rg, Rh and Ri are, at each occurrence, independently selected from the group consisting of:
• halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, and C1-4 haloalkoxy;
• Rj is, at each occurrence, independently selected from the group consisting of:
• C1-4 alkyl, C3-4 cycloalkyl and phenyl;
• n, at each occurrence, is independently 0 or 1;
• m, at each occurrence, is independently 0, 1, 2, 3, or 4
• s, at each occurrence, is independently 1, 2, or 3;
• and
• t, at each occurrence, is independently 0 or 1;
• provided that the following compound is excluded: