Biomaterials having nanoscale layers and coatings
AssigneeWashington University
InventorsDonald Elbert, Megan Kaneda, Evan Scott, Brad Wacker, Shannon Alford
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Abstract
The invention generally relates to substrates and surfaces having substrates. Generally speaking, the substrates may be thinly layered substrates, and the surfaces may comprise thinly layered substrates. Additionally, the substrates may comprise a multifunctional water soluble polymer and a lipoprotein and the surfaces may comprise a multifunctional water soluble polymer and a lipoprotein.
Claims44
A substrate comprising a plurality of cross-linked, distinctly-formed layers, the plurality of cross-linked, distinctly-formed layers comprising at least three layers wherein the at least three layers comprise
- a first water soluble polymer layer, a second protein layer, and a third water soluble polymer layer,
- wherein the first water soluble polymer layer comprises a water soluble polymer that comprises a reactive group selected from the group consisting of sulfones, sulfoxides, sulfonates, sulfonamides, phosphonates and phosphonamides;
- the second protein layer comprises at least one protein that comprises at least one lipid binding site and at least one functional group selected from the group consisting of an amino group and a sulfhydryl group;
- and
- the third water soluble polymer layer comprises a water soluble polymer that comprises a reactive group selected from the group consisting of sulfones, sulfoxides, sulfonates, sulfonamides, phosphonates and phosphonamides;
- and
- whereby the second protein layer is disposed between the first water soluble polymer layer and the third water soluble polymer layer to cross-link the first water soluble polymer layer and the third water soluble polymer layer together to form the plurality of cross-linked, distinctly-formed layers.
A surface which is a material selected from the group consisting of a metal, glass, a silicon containing material, iron oxide, titanium oxide and silicon oxide, comprising a plurality of cross-linked, distinctly-formed layers, the plurality of cross-linked, distinctly-formed layers comprising at least three layers wherein the at least three layers comprise
- a first water soluble polymer layer, a second protein layer, and a third water soluble polymer layer,
- wherein the first water soluble polymer layer comprises a water soluble polymer that comprises a reactive group selected from the group consisting of sulfones, sulfoxides, sulfonates, sulfonamides, phosphonates and phosphonamides;
- the second protein layer comprises at least one protein that comprises at least one lipid binding site and at least one functional group selected from the group consisting of an amino group and a sulfhydryl group;
- and
- the third water soluble polymer layer comprises a reactive group selected from the group consisting of sulfones, sulfoxides, sulfonates, sulfonamides, phosphonates and phosphonamides;
- and
- whereby the second protein layer is disposed between the first water soluble polymer layer and the third water soluble polymer layer to cross-link the first water soluble polymer layer and the third water soluble polymer layer together to form the plurality of cross-linked, distinctly-formed layers.
Dependencies are inferred from the claim text.