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US 8,790,658 B2Granted
Antigen-adjuvant compositions and methods
AssigneeSanofi Pasteur Limited
InventorsSandrine Cigarini, Kevin Harper, Manvi Hasija
Life of this patent
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Abstract
Vitreous compositions of an antigen and adjuvant, and methods for making the compositions are disclosed. Also disclosed are pharmaceutically acceptable formulations of the vitreous compositions, reconstituted liquid formulations of the vitreous compositions, vaccine compositions, and kits containing the vitreous compositions. Also disclosed are devices for administering the vitreous compositions to mammals and methods for eliciting an immune response in mammals by administering the compositions.
Claims8
A method for preparing a vitreous composition of an antigen and an adjuvant, comprising:
- a) preparing a first liquid by incubating, storing, or mixing at least one antigen and at least one adjuvant at 2-8° C. for at least 24 hours;
- b) subsequently adding at least one polyol or synthetic polymer to the first liquid to prepare a second liquid;
- c) subsequently drying the second liquid at ambient temperature under low vacuum;
- and,
- d) subsequently boiling the product of c) under a high vacuum to form a foam.
2 more elements
Dependencies are inferred from the claim text.