Repair and regeneration of ocular tissue using postpartum-derived cells
AssigneeDePuy Synthes Products, Inc.
InventorsSanjay Mistry, Darin Messina
Life of this patent
Estimating the term…
Abstract
Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
Claims20
A method for treating damage to the optic nerve in a patient having glaucoma, the method comprising administering to the damaged optic nerve isolated umbilicus-cells isolated from human umbilical cord tissue substantially free of blood, in an amount effective to treat the damage, wherein the cells are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a neural phenotype, maintain a normal karyotype upon passaging, and have the following characteristics:
- a) potential for at least 40 population doublings in culture;
- b) production of CD10, CD13, CD44, CD73, and CD90;
- c) lack of production of CD31, CD34, CD45, CD117 and CD141, and
- d) increased expression of genes encoding interleukin 8 and reticulon 1 relative to a human cell that is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.
A method for reducing the loss of photoreceptor cells in a patient with a retinal degeneration, the method comprising administering to the interior of the patient's eye isolated umbilicus cells isolated from human umbilical cord tissue substantially free of blood, in an amount effective to reduce the loss of photoreceptor cells, wherein the umbilicus cells are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a neural phenotype, maintain a normal karyotype upon passaging, and have the following characteristics:
- a) potential for at least 40 population doublings in culture;
- b) production of CD10, CD13, CD44, CD73, and CD90;
- c) lack of production of CD31, CD34, CD45, CD117, and CD141, and
- d) increased expression of genes encoding interleukin 8 and reticulon 1 relative to a human cell that is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell.
Dependencies are inferred from the claim text.