# US 8,788,041 B2 · Methods and compositions for treating a disease condition in a subject

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,788,041 B2
- Document ID: US8788041B2
- Status: Granted
- Kind: B2
- Application number: 12/886,327
- Filed: 2010-09-20
- Published: 2011-02-03
- Granted: 2014-07-22
- Earliest claimed: 2004-10-15
- Assignees: Palo Alto Investors
- Applicants: Anthony Joonkyoo Yun; Patrick Yuarn-Bor Lee
- Inventors: Anthony Joonkyoo Yun; Patrick Yuarn-Bor Lee
- Web page: https://patentgrep.com/patent/US8788041B2

## CPC

- A61M 5/14276: {specially adapted for implantation}
- A61K 31/395: having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K 31/4168: having a nitrogen attached in position 2, e.g. clonidine
- A61K 31/4188: condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
- A61K 31/475: having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine (vincamine A61K31/4375)
- A61N 1/3605: {Implantable neurostimulators for stimulating central or peripheral nerve system}
- A61N 1/36117: {for treating hypertension}
- A61P 9/12: Antihypertensives
- A61M 2205/054: with electrotherapy
- A61N 1/05: for implantation or insertion into the body, e.g. heart electrode (A61N1/06 takes precedence)
- A61N 1/18: Applying electric currents by contact electrodes
- A61N 1/36002: {Cancer treatment, e.g. tumour}
- A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Methods for treating a disease condition in a subject are provided. The subject methods are characterizing by enhancing at least one symptom of the disease condition in a manner effective to cause the subject to mount a compensatory response effective to treat the disease condition. Also provided are compositions, kits and systems for practicing the subject methods.

## Claims

### Claim 1

A method of treating a subject for hypertension, said method comprising
enhancing at least one symptom of hypertension by applying electrical stimulus to sympathetic nerves of said subject;
removing said stimulus to provide a holiday period which permits said subject to mount a compensatory response characterized by a decrease in said symptom;
monitoring said compensatory response; and
repeating said enhancing, removing, and monitoring in a manner effective to treat hypertension,
wherein said stimulus is applied in a irregularly irregular manner and the duration of holiday periods varies randomly over the entire course of a treatment.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the holiday period is 1 day or longer.

### Claim 3 (depends on 2)

The method according to claim 2, wherein the holiday period is 5 days or longer.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the stimulus is applied for one week or less.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the stimulus is applied for 3 days or less.

### Claim 6 (depends on 1)

The method according to claim 1, wherein the stimulus is applied for 1 day or less.

### Claim 7 (depends on 1)

The method according to claim 1, wherein the applying is pulsatile.

### Claim 8 (depends on 1)

The method according to claim 1, wherein the symptom is enhanced two-fold or more.