# US 8,788,029 B2 · Heart analysis method and apparatus > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,788,029 B2 - Document ID: US8788029B2 - Status: Granted - Kind: B2 - Application number: 11/664,621 - Filed: 2005-10-05 - Published: 2008-08-14 - Granted: 2014-07-22 - Earliest claimed: 2004-10-05 - Assignees: Cuoretech Pty Ltd. - Applicants: Andrew Madry; Stuart Philip Thomas - Inventors: Andrew Madry; Stuart Philip Thomas - Web page: https://patentgrep.com/patent/US8788029B2 ## CPC - A61B 5/02405: {Determining heart rate variability} - A61B 5/287: Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS] - A61B 5/341: Vectorcardiography [VCG] - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A method and device for monitoring heart behavior. In particular, a visual aid for clinician in which regions of the heart having aberrant characteristics can be displayed. A number of electrodes are positioned near/on an endocardium; electrical signals from the electrodes are monitored and recorded. A variability of a time varying parameter is calculated from each electrode location and displayed on a cardiac image. A user can select the parameter and measurement properties of the parameter, wherein the variability of the parameter is displayed and aberrant behavior can be detected. ## Claims ### Claim 1 A method of identifying cardiac regions having aberrant conductive properties including steps of: measuring a plurality of electrical signals from an endocardium wherein the measuring includes a time sequence; recording positions of each electrical signal; calculating a time varying parameter from the measured time sequence of electrical signals; computing a time-series variability of the time varying parameter over a selected duration from said electrical signals to thereby monitor the temporal variability of the time varying parameter which represents the continuous variation of an instantaneous value of the time varying parameter; and displaying said time-series variability at said positions on a cardiac image. ### Claim 2 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of allowing a user to select said parameter and select a graphical representation for said time-series variability. ### Claim 3 (depends on 2) The method of identifying cardiac regions having aberrant conductive properties of claim 2 further including a step of displaying changes in said time-series variability by displaying changes in said graphical representation of said time-series variability. ### Claim 4 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of recording variability for each said position and displaying said time-series variability for each position in real time. ### Claim 5 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of recording a time sequence of variability for each said position and displaying said time sequence in real time. ### Claim 6 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of displaying said cardiac image using an anatomical map and said time-series variability using a waterfall plot. ### Claim 7 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of allowing a user to select a region on said cardiac image and activating at least one popup display, displaying said time-series variability of selected region. ### Claim 8 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of displaying said time-series variability of a cardiac electrogram. ### Claim 9 (depends on 8) The method of identifying cardiac regions having aberrant conductive properties of claim 8 further including a step of receiving electrogram signals from said electrodes and computing a fiducial point. ### Claim 10 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of allowing a user to select said parameter and select a measurement property of said parameter. ### Claim 11 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of computing time-series variability of a wavefront velocity and wavefront direction. ### Claim 12 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 further including a step of allowing a user to select a visual persistence factor of said time-series variability. ### Claim 13 (depends on 1) The method of identifying cardiac regions having aberrant conductive properties of claim 1 wherein the time series variability is selected from the group consisting of a standard deviation, degree of entropy, degree of chaos and a correlation dimension. ### Claim 14 A system of identifying cardiac regions having aberrant conductive properties including: a plurality of electrodes measuring electrical signals from an endocardium wherein the measuring includes a time sequence; a recording device recording a position for each electrical signal; a calculating device calculating a time varying parameter from the measured time sequence of electrical signals; a computing device calculating a time-series variability of a time varying parameter over a selected duration from said electrical signals to thereby monitor the temporal variability of the time varying parameter which represents the continuous variation of an instantaneous value of the time varying parameter; and a display device displaying said time-series variability at said position on a cardiac image. ### Claim 15 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said display device allows a user to select said parameter and select a graphical representation for said time-series variability. ### Claim 16 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said display device displays changes in said time-series variability by displaying changes in said graphical representation of said time-series variability. ### Claim 17 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said recording device records a time sequence of variability for each said position and displays said time sequence in real time on said display device. ### Claim 18 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said display device displays said cardiac image using an anatomical map and the time-series variability using a waterfall plot. ### Claim 19 (depends on 13) The system of identifying cardiac regions having aberrant conductive properties of claim 13, wherein said display device allows a user to select a region on said cardiac image and activates a popup display of said time-series variability of selected region. ### Claim 20 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said display device displays said time-series variability at said position over said cardiac image. ### Claim 21 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said display device displays said time-series variability of a cardiac electrogram. ### Claim 22 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said electrodes measure the electrogram signals from said endocardium and said computing device calculating a fiducial point. ### Claim 23 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said display device allows a user to select said parameter and select a measurement property of said parameter. ### Claim 24 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said computing device calculates time-series variability of a wavefront velocity and wavefront direction. ### Claim 25 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14, wherein said display device allowing a user to select a visual persistence factor of said time-series variability. ### Claim 26 (depends on 14) The system of identifying cardiac regions having aberrant conductive properties of claim 14 wherein the time series variability is selected from the group consisting of a standard deviation, degree of entropy, degree of chaos and a correlation dimension. ### Claim 27 A computer program having a computer readable medium having a computer program logic recorded thereon for identifying cardiac regions having aberrant conductive properties, said computer program product comprising: means for measuring a plurality of electrical signals from an endocardium wherein the measuring includes a time sequence; means for recording positions of each electrical signal; means for calculating a time varying parameter from the measured time sequence of electrical signals; means for calculating a time-series variability of a time varying parameter over a selected duration from said electrical signals to thereby monitor the temporal variability of the time varying parameter which represents the continuous variation of an instantaneous value of the time varying parameter; means for displaying said time-series variability at said positions on a cardiac image. ### Claim 28 (depends on 27) A computer program having a computer readable medium having a computer program logic recorded thereon for identifying cardiac regions having aberrant conductive properties, said computer program product as recited in claim 27 further comprising means for allowing a user to select said parameter and select a graphical representation for said time-series variability. ### Claim 29 (depends on 27) A computer program having a computer readable medium having a computer program logic recorded thereon for identifying cardiac regions having aberrant conductive properties, said computer program product as recited in claim 27 further comprising means for displaying changes in said time-series variability by displaying changes in said graphical representation of said time-series variability. ### Claim 30 (depends on 27) A computer program having a computer readable medium having a computer program logic recorded thereon for identifying cardiac regions having aberrant conductive properties, said computer program product as recited in claim 27 further comprising means for allowing a user to select said time series variability from the group consisting of a standard deviation, degree of entropy, degree of chaos and a correlation dimension. ### Claim 31 A cardiac monitor comprising: a plurality of electrodes arranged over an endocardial surface; a signal receiver adapted to detect a time-series of electrical signals from said electrodes; a detection device tracking positions of each said electrode of the plurality of electrodes; a calculating device calculating a time varying parameter from the measured time sequence of electrical signals; a computer device calculating a time-series variability of a time varying parameter over a selected duration from said electrical signals to thereby monitor the temporal variability of the time varying parameter which represents the continuous variation of an instantaneous value of the time varying parameter; and a visual device displaying said time-series variability at said positions on a cardiac image. ### Claim 32 (depends on 31) The cardiac monitor as recited in claim 31 wherein said computer device allows a user to select said parameter and select an indicia for said time-series variability. ### Claim 33 (depends on 32) The cardiac monitor as recited in claim 32 wherein said visual device displays changes in said time-series variability by displaying changes in said indicia. ### Claim 34 (depends on 31) The cardiac monitor as recited in claim 31 wherein the time series variability is selected from the group consisting of a standard deviation, degree of entropy, degree of chaos and a correlation dimension.