# US 8,788,015 B2 · Method of rapidly visualizing essential neural pathways

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- Number: US 8,788,015 B2
- Document ID: US8788015B2
- Status: Granted
- Kind: B2
- Application number: 13/366,579
- Filed: 2012-02-06
- Published: 2012-07-05
- Granted: 2014-07-22
- Earliest claimed: 2009-08-05
- Assignees: University of South Florida
- Applicants: Surbhi Jain; Steven Brem
- Inventors: Surbhi Jain; Steven Brem
- Web page: https://patentgrep.com/patent/US8788015B2

## CPC

- G01R 33/56341: {Diffusion imaging}
- G01R: MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES (indicating correct tuning of resonant circuits H03J3/12)

## Abstract

A method of optimizing pre-operative procedures in the field of neurosurgery. The method facilitates the identification of essential fiber tract pathways that must be avoided when planning and performing an operation, thereby increasing surgical safety and avoiding complications. The method includes the combined use of four variables in Diffusion Tensor Imaging (DTI)-Fiber Tracking (FT) of projection fibers in the brain. These variables include Jain-Brem™ fractional anisotropy constant for tractography (JB-FACT), Jain-Brem™ fiber length (JB-FL), subcentimeter size placement of regions of interest (ROI), and the placement of ROIs to cover the anatomical pathway of projection fibers. JB-FACT and JB-FL provide rapid, reproducible tracking for projection fibers in the brain.

## Claims

### Claim 1

A non-transitory computer readable medium for performing a method by running a software program on a computer, the computer readable medium comprising instructions for a computer to transform magnetic resonance imaging data into a visualization of neural pathways in the brain for tractography by diffusion tensor imaging or fiber tracking, the instructions comprising:
obtaining a magnetic resonance imaging data representing a first plurality of brain fiber tracts;
accessing a plurality of variable fields within the software, the variable fields including a fractional anisotrophy ratio field and a fiber length field;
setting the fractional anisotropy ratio field to a constant of about 0.26;
setting the fiber length field to a constant of about 60 mm;
determining positional coordinates and orientations of the first plurality of brain fiber tracts by applying the constants set for the fractional antisotrophy ratio and the fiber length fields to the magnetic resonance imaging data;
generating an electronic image representing the first plurality of brain fiber tracts using the calculated positional coordinates and orientations thereof; and
outputting the electronic image in a visual form.

### Claim 2 (depends on 1)

The computer readable storage medium of claim 1 further comprising instructions for setting a region of interest to a sub-centimeter size.

### Claim 3 (depends on 1)

The computer readable storage medium of claim 1 further comprising instructions for placing sub-centimeter sized regions of interest to cover an anatomical pathway of projection fibers.

### Claim 4 (depends on 1)

The computer readable storage medium of claim 1, wherein the first plurality of brain fiber tracts belongs to a predefined fiber bundle.

### Claim 5 (depends on 4)

The computer readable storage medium of claim 4, wherein the fiber bundle is selected from the group consisting of commissural, association, and projection fibers.

### Claim 6 (depends on 4)

The computer readable storage medium of claim 4, wherein the fiber bundle comprises corticospinal, corticobulbar, or corticopontine fibers.

### Claim 7 (depends on 1)

The computer readable storage medium of claim 1, wherein the electronic image is displayed on a monitor.