# US 8,785,695 B2 · Method for purifying compounds containing amino groups

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- Number: US 8,785,695 B2
- Document ID: US8785695B2
- Status: Granted
- Kind: B2
- Application number: 13/515,883
- Filed: 2010-12-13
- Published: 2012-10-04
- Granted: 2014-07-22
- Earliest claimed: 2009-12-17
- Assignees: BASF SE
- Applicants: Martin Völkert; Burkhard Ernst; Wolfgang Siegel
- Inventors: Martin Völkert; Burkhard Ernst; Wolfgang Siegel
- Web page: https://patentgrep.com/patent/US8785695B2

## CPC

- C07C 249/02: of compounds containing imino groups
- C07C 45/516: {involving transformation of nitrogen-containing compounds to >C = O groups}
- C07C 209/84: Purification
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Method for purifying compounds (I) containing amino groups from a polar phase A, where (I) is converted by reaction with an aldehyde or ketone (II) into the corresponding imine (III) which is insoluble or sparingly soluble in the polar phase A, and then the imine (III) is converted to a nonpolar phase B and separated off from phase A, and then the compound containing amino groups is recovered from the imine (III).

## Claims

### Claim 1

A method for purifying a diaminoalkyl compound (I), said method comprising:
i) preparing said compound (I) by fermentation in an aqueous phase A;
ii) converting said compound (I) through reaction with an aldehyde or ketone (II) into the corresponding imine (III) which is insoluble or sparingly soluble in the polar phase A;
iii) transferring the imine (III) to a nonpolar phase B;
iv) separating off from phase A; and
v) recovering said compound (I) from the imine (III).

### Claim 2 (depends on 1)

The method according to claim 1, wherein the diaminoalkyl is 1,5-diaminopentane.

### Claim 3 (depends on 1)

The method according to claim 1, wherein benzaldehyde is used as (II).

### Claim 4 (depends on 2)

The method according to claim 2, wherein benzaldehyde is used as (II).

### Claim 5 (depends on 1)

The method according to claim 1, wherein step v) is effected by adding an acid.

### Claim 6 (depends on 4)

The method according to claim 4, wherein step v) is effected by adding an acid.

### Claim 7 (depends on 5)

The method according to claim 5, where the acid is added in equimolar amounts based on (I).

### Claim 8 (depends on 6)

The method according to claim 6, where the acid is added in equimolar amounts based on (I).