Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors

A compound of Formula I:

• Wherein
• Z1 is selected from the group consisting of CR2a and N;
• Z2 is selected from the group consisting of CR2b and N;
• Z3 is selected from the group consisting of CR2c and N;
• wherein if Z1 is N, then one or both of Z2 or Z3 is also N with the proviso that at least 1 of Z1, Z2, or Z3 must be N;
• m is selected from the group consisting of 0, 1, 2, or 3;
• R1 is independently selected from the group consisting of chloro, fluoro, and bromo;
• R2a, R2b, and R2c, are independently selected from the group consisting of hydrogen, halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and N(CH3)2;
• X is selected from the group consisting of
• n is selected from 0, 1, and 2;
• R3 is independently selected from the group consisting of halogen, C1-C3 alkyl, fluorinated C1-C3 alkyl, cyano, C1-C3 alkoxy, and NR4R4′ where R4 and R4′ are independently selected from the group consisting of C1-C3 alkyl, or R4 when taken together with R4′ form a ring with 3 to 6 members;
• A is selected from the group consisting of
• or a pharmaceutically acceptable salt, stereoisomer, or N-oxide thereof.