# US 8,785,569 B2 · Drug carrier with chelating complex micelles and the application thereof

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- Number: US 8,785,569 B2
- Document ID: US8785569B2
- Status: Granted
- Kind: B2
- Application number: 13/683,482
- Filed: 2012-11-21
- Published: 2013-05-23
- Granted: 2014-07-22
- Earliest claimed: 2011-11-22
- Assignees: Original Biomedicals Co., Ltd
- Applicants: Original Biomedicals, Co., Ltd.
- Inventors: Chau-Hui Wang; Chia-Hung Chen; Johnson Lin; Jing-Yi Chen; Wei-Chuan Liao
- Web page: https://patentgrep.com/patent/US8785569B2

## CPC

- A61K 47/547: {Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent}
- A61K 31/661: Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion {or mevinphos}
- A61K 47/52: the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
- A61K 47/59: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K 47/593: {Polyesters, e.g. PLGA or polylactide-co-glycolide}
- A61K 47/60: the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A61K 47/6907: {the form being a microemulsion, nanoemulsion or micelle}
- A61P 35/00: Antineoplastic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.

## Claims

### Claim 1

A chelating complex micelle for carrying a Lewis base drug, comprising:
a Lewis base polymer; and
a ligand free metal ion core, wherein the metal ion core is a Lewis acid selected from one or any combination of the group consisting of the following: Fe, Cu, Ni, In, Ca, Co, Cr, Gd, Al, Sn, Zn, W, Sc, Ti, Mn, V, Mg, Be, La, Au, Ag, Cd, Hg, Pd, Re, Tc, Cs, Ra, Ir, Ga, wherein the metal ion core and the Lewis base polymers bind to each other by coordinate bonds, wherein the metal ion core links to the Lewis base drug via coordinate bonding.

### Claim 2 (depends on 1)

The chelating complex micelle of claim 1, wherein the polymer is selected from a group of unidentate ligand, bidentate ligands, tridentate ligands, hexadentate ligands, and polydentate ligands.

### Claim 3 (depends on 1)

The chelating complex micelle of claim 1, wherein the polymer's molecular weight ranges from 1,000 to 100,000 Daltons.

### Claim 4 (depends on 1)

The chelating complex micelle of claim 1, wherein the polymer is copolymer of poly(ethylene glycol) and poly(glutamic acid).