# US 8,785,504 B2 · 4-hydroxy benzoate derivatives for use in the treatment of infection, inflammation or pain

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- Number: US 8,785,504 B2
- Document ID: US8785504B2
- Status: Granted
- Kind: B2
- Application number: 12/663,451
- Filed: 2008-06-12
- Published: 2010-11-18
- Granted: 2014-07-22
- Earliest claimed: 2007-06-20
- Applicants: Roy Arlington Jordan
- Inventors: Roy Arlington Jordan
- Web page: https://patentgrep.com/patent/US8785504B2

## CPC

- C07C 65/03: monocyclic and having all hydroxy or O-metal groups bound to the ring
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0043: {Nose}
- A61K 9/0048: {Eye, e.g. artificial tears}
- A61K 9/0056: {Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals}
- A61P 11/02: Nasal agents, e.g. decongestants
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 17/04: Antipruritics
- A61P 17/06: Antipsoriatics
- A61P 17/10: Anti-acne agents
- A61P 19/06: Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- C07C 51/412: {by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part}
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A compound of the general formula (I) is provided for use in the topical treatment of infection, inflammation and/or pain: wherein R1 independently represents a methylene group, an ethylene group or a straight or branched chain C3 to C6 alkylene group; R2 independently represents a hydrogen atom, a methyl group, an ethyl group or a straight or branched chain C3 to C20 alkyl group; x represents 0 or an integer from 1 to 4 and y represents 0 or an integer from 1 to 4, wherein the sum of x and y is 4; and Z represents a hydrogen atom or (HOR1)yR2xN+; compositions including the compound; use of the compound in the manufacture of a medicament; and methods of medical treatment including the topical application of the compound.

## Claims

### Claim 1

A method for the topical treatment of infection, inflammation or pain in a human or an animal comprising an application of a therapeutically effective amount of a compound of formula (I) or a composition comprising a compound of formula (I) to the human or animal in need of such treatment, wherein formula (I) is represented by:

### Claim 2 (depends on 1)

The method according to claim 1 wherein the treatment is for eczema, psoriasis, acne, sunburn, a wound, bruising, a burn, gout, ringworm, a cold sore, impetigo, a symptom associated with the common cold or influenza, gum disease, cystic fibrosis, epidermolysis bullosa, bacterial infection, geographic tongue, an adverse reaction to an insect bite or sweet itch.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the compound or composition is applied to an area of the human or animal to be treated by:
(i) rubbing the composition into the area to be treated, or
(ii) spraying an aqueous composition of the compound of formula (I) onto the area to be treated.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the method comprises applying the composition comprising the compound of formula (I).

### Claim 5 (depends on 4)

The method according to claim 4, wherein the compound according formula (I) is present up to 60% by weight of the composition.

### Claim 6 (depends on 4)

The method according to claim 4, wherein the compound according to formula (I) is present at 0.2 to 10% by weight of the composition.

### Claim 7 (depends on 4)

The method according to claim 4, wherein the composition comprises a pharmaceutically acceptable carrier.

### Claim 8 (depends on 4)

The method according to claim 4, wherein the composition comprises glycerol.