# US 8,785,488 B2 · Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 8,785,488 B2 - Document ID: US8785488B2 - Status: Granted - Kind: B2 - Application number: 13/148,811 - Filed: 2010-02-12 - Published: 2012-02-16 - Granted: 2014-07-22 - Earliest claimed: 2009-02-12 - Assignees: Exelixis Patent Company LLC - Applicants: Venkataiah Bollu; Brant Clayton Boren; Jackaline Dalgard Julien; Brenton T. Flatt; Nadia Haq; Sarah Hudson; Raju Mohan; Michael Morrissey; Benjamin Pratt; Tie-Lin Wang; Richard Martin; Xiao-Hui Gu - Inventors: Venkataiah Bollu; Brant Clayton Boren; Jackaline Dalgard Julien; Brenton T. Flatt; Nadia Haq; Sarah Hudson; Raju Mohan; Michael Morrissey; Benjamin Pratt; Tie-Lin Wang; Richard Martin; Xiao-Hui Gu - Web page: https://patentgrep.com/patent/US8785488B2 ## CPC - C07D 233/84: Sulfur atoms - A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics - A61P 3/00: Drugs for disorders of the metabolism (of the blood or the extracellular fluid A61P7/00) - A61P 3/04: Anorexiants; Antiobesity agents - A61P 3/06: Antihyperlipidemics - A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48) - A61P 3/10: for hyperglycaemia, e.g. antidiabetics - A61P 5/50: for increasing or potentiating the activity of insulin - A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis - A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 - C07D 233/64: with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine - C07D 233/90: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals - C07D 249/12: Oxygen or sulfur atoms - C07D 401/04: directly linked by a ring-member-to-ring-member bond - C07D 401/12: linked by a chain containing hetero atoms as chain links - C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms - C07D 403/14: containing three or more hetero rings - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) - A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS ## Abstract The present invention comprises TGR5 agonists of structural formula I, wherein X, R1, R2, and R5 are defined herein, as well as N-oxides of them and pharmaceutically acceptable salts thereof. The invention further comprises composition comprising the compounds, N-oxides, and/or pharmaceutically acceptable salts thereof. The invention also comprises use of the compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which TGR5 is a mediator or is implicated. ## Claims ### Claim 1 A compound of Formula VIII: or pharmaceutically acceptable salt thereof, wherein: X is ═C(R4)—; R1 is RC; or X can be ═C(RC)— only when R1 is phenyl optionally substituted with one, two, or three RC10 groups; RC is selected from phenyl, —(C5-C6)-cycloalkyl, —CH2-phenyl, heteroaryl, optionally substituted with —ORC13, —N(RC13)2 or —S(RC13), wherein the cyclic group of RC can be optionally substituted with 1, 2, 3, 4 or 5 RC10 groups, wherein the 1, 2, 3, 4, or 5 RC10 groups are independently selected from RC10A and RC10B, provided that RC cannot be substituted with more than 2 RC10B groups, and provided that substitution of RC with RC10 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of RC, wherein each RC10A is independently selected from halo, cyano and —(C1-C4)alkyl optionally substituted with 1-3 groups selected from —OH and halo; each RC10B is independently selected from —C(O)NH2, (5-6 membered)heterocycloalkyl, —O—(C1-C4)alkyl-RC11, —C(O)ORC12, —OC(O)ORC12 and —O—(C1-C4)alkyl optionally substituted with —OH or —C(O)OH; RC11 is cyano, nitro, —N(RC12)2, —ORC12, —SRC12, —C(O)RC12, —C(O)ORC12, —C(O)N(RC12)2, —S(O)N(RC12)2, —S(O)2N(RC12)2, —S(O)2RC12, —OC(O)RC12, —OC(O)ORC12, —OC(O)N(RC12)2, —N(RC12)C(O)RC12, —N(RC12)C(O)ORC12, —N(RC12)C(O)N(RC12)2, or —N(RC12)C(═NRC12)N(RC12)2; each RC12 is independently selected from hydrogen, —(C1-C4)alkyl, and —(C1-C4)haloalkyl; each RC13 is independently selected from hydrogen, —(C1-C4)alkyl, and —(C1-C4)haloalkyl; R2 is -LD-RD1; LD is —[C(R)2]p—Y—[C(R)2]q—; p is 0 or 1: q is 0 or 1; each R is independently selected from H, —(C1-C3)alkyl, halo, —OH, and —CH2OH; Y is a bond, —S—, —S(O)2—, —CH(OH)—, —O—, —C(H)═C(H)—, —C(O)—(C1-C4)alkyl-, —(C1-C4)alkyl-S—(C1-C4)alkyl-, —(C1-C4)alkyl-N(RY)—(C1-C4)alkyl-, —C(H)(halo)-, —(C1-C4)alkyl-S(O)2—, —S(O)2—N(RY)—, —(C1-C4)alkyl-O—, or —C(O)—N(RY)—, wherein RY is H, —(C1-C4)alkyl, hydroxyl(C1-C4)alkyl or —C≡C—(C1-C3)alkyl-; RD1 is selected from —(C6-C10)aryl, —N(H)-phenyl, cycloalkyl, heterocycloalkyl, and heteroaryl, wherein RD1 can be optionally substituted with 1, 2, 3, 4 or 5 RD10, provided that substitution of RD1 with RD10 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of RD1, wherein the 1-5 RD10 groups are independently selected from A groups and B groups, provided that RD1 cannot be substituted with more than 2 B groups; each A group, when they occur, is independently selected from halo, —CF3, —CN, —NO2, —OH, —NH2, —O—(C1-C4)alkyl optionally substituted at the alkyl group with 1-3 substituents independently selected from —OH and halo, and —(C1-C4)alkyl optionally substituted with 1-3 substituents independently selected from —OH and halo; each B group, when they occur, is independently selected from —(C1-C4)alkylN(RD11)2, —C(O)—NH2, —C(O)—N(H)—OH, —C(O)—N(H)—RD11C, —C(O)—(C1-C4)alkyl optionally substituted with RD11B, —C(O)OH, —S(O)2—(C1-C4)alkyl-N(RD11)2, —S(O)2—N(RD11)RD11C, —S(O)2—N(H)C(O)—N(RD11)RD11B, —C(═NH)—NH2, —C(O)O—(C1-C4)alkyl optionally substituted with RD11B, —O—(C1-C4)alkyl optionally substituted at the alkyl group with 1 or 2 RD11B, —C(O)-heterocycloalkyl, wherein the —C(O)-heterocycloalkyl can be optionally substituted with RD11B, provided that substitution of —C(O)-heterocycloalkyl with RD11B can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of —C(O)-heterocycloalkyl, —C(O)—N(H)—(C1-C6)alkyl optionally substituted at the alkyl group with 1 or 2 RD11B, heterocycloalkyl optionally substituted with oxo or RD11, provided that substitution of the heterocycloalkyl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the heterocycloalkyl, heterocycloalkenyl optionally substituted with oxo or RD11, provided that substitution of the heterocycloalkenyl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the heterocycloalkenyl, heteroaryl optionally substituted with RD11, provided that substitution of the heteroaryl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the heteroaryl, —S(O)2-(4-6 membered)heterocycloalkyl optionally substituted with RD11C provided that substitution of the —S(O)2-(4-6 membered)heterocycloalkyl with RD11C can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the —S(O)2-(4-6 membered)heterocycloalkyl, —S(O)2—N(H)C(O)—(C1-C4)alkyl optionally substituted with RD11B, —S(O)2—N(H)C(O)O—(C1-C4)alkyl optionally substituted with RD11B, —S(O)2—(C1-C4)alkyl optionally substituted with RD11B, —N(H)—C(O)—(C1-C4)alkyl optionally substituted at the alkyl group with 1 or 2 RD11B, —N(H)—C(O)—N(H)—(C1-C3)alkyl optionally substituted at the alkyl group with RD11B, —(C1-C6)alkyl optionally substituted with 1 or 2 RD11B, and —C≡C—(C1-C3)alkyl optionally substituted with RD11B; each RD11 is independently selected from H, —(C3-C6)cycloalkyl, —OH, —(C1-C4)haloalkyl, —(C1-C4)alkyl optionally substituted with halo, —OH, —C(O)OH, —S(O)2OH, C(O)OH, —NH2, or —N(H)C(═NH)NH2, and —(C1-C3)alkyl-phenyl optionally substituted at the phenyl group with 1-3 substituents selected from methoxy, hydroxyl and halo; RD11B is selected from H, —OH, —CF3, a PEG polymer, —N(RD11)2, —C(O)OH, —O—(C1-C4)alkyl, —S(O)2OH, —C(═NH)—NH2, —N(H)C(═NH)NH2, —C(H)═NC(═NH)NH2, —C(H)═NN(H)C(═NH)NH2, —N(H)C(═NH)—N(H)C(═NH)NH2, —C(O)—(C1-C3)alkyl, —O—(C1-C4)alkyl-C(O)OH, (5-6 membered)heteroaryl, —(C1-C4)alkyl optionally substituted with 1-3 groups independently selected from halo, —OH, —S(O)2OH, C(O)OH, —NH2, and —N(H)C(═NH)NH2, —(C0-C3)alkyl-(5-8 membered)heterocycloalkyl, optionally substituted with 1, 2 or 3 RD11, provided that substitution of —(C0-C3)alkyl-(5-8 membered)heterocycloalkyl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of —(C0-C3)alkyl-(5-8 membered)heterocycloalkyl, —(C0-C3)alkyl-(C3-C6)cycloalkyl optionally substituted with RD11, and aryl optionally substituted with 1-5 halo; or RD11 and RD11B, when they both exist and are each attached to nitrogen, can join together with the nitrogen to which they are attached to form a (5-6 membered) heterocycloalkyl optionally substituted with a group selected from —(C3-C6)cycloalkyl, —(C1-C4)haloalkyl, —OH, —S(O)2OH, C(O)OH, —NH2, —N(H)C(═NH)NH2, —(C1-C4)alkyl optionally substituted with halo, —OH or —C(O)OH, and —(C1-C3)alkyl-phenyl optionally substituted at the phenyl group with 1-3 substituents selected from methoxy, hydroxyl and halo, provided that substitution of the (5-6 membered) heterocycloalkyl can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the (5-6 membered) heterocycloalkyl; RD11C is selected from H, —OH, —CF3, —O—(C1-C4)alkyl, —(C1-C4)alkyl-N(H)C(═NH)—NH2, —(C0-C3)alkyl-(5-6 membered)heteroaryl, —(C1-C4)alkyl optionally substituted with 1-3 groups independently selected from halo, —OH, —S(O)2OH, C(O)OH, —NH2, and —N(H)C(═NH)NH2, —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl optionally substituted with one (5-6 membered)heteroaryl, provided that substitution of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl with (5-6 membered)heteroaryl can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl, —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl substituted with 1, 2 or 3 groups selected from —OH and —(C1-C3)alkyl, provided that substitution of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl, and —(C0-C3)alkyl-aryl optionally substituted at the aryl group with 1-3 halo; R4 is H, —(C1-C3)alkyl or halo; R5 is —[C(R8)2]-phenyl, —[C(R8)2]-naphthalenyl, or —[C(R8)2]-(5-10 membered) heteroaryl, wherein the heteroaryl is selected from (benzo[d][1,3]dioxolyl, benzo[d]isoxazole, quinoxalinyl, quinolinyl and 2,3,4a,8a-tetrahydrobenzo[b][1,4]dioxinyl, wherein the cyclic group of R5 is optionally substituted with 1, 2, 3, 4 or 5 RA10, provided that substitution of R5 with RA10 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of R5, wherein the 1-5 RA10 groups are independently selected from RA10A groups and RA10B groups, provided that R5 cannot be substituted with more than 2 RA10B groups; each RA10A, when they occur, is independently selected from halo, alkoxyl, hydroxyl, —CN, —OCF3, —(C1-C4)alkyl and —NH2, each RA10B, when they occur, is selected from —O—(C1-C4)alkyl-RA11, —S(O)2—NH2, —S(O)2CH3, —N(H)—S(O)2CH3, —S(O)2N(H)—CH3, —C(O)OH, —(C1-C4)alkyl-OH, —C(O)NH2, and —(C1-C4)alkyl substituted with 1-3 groups selected from —OH and halo; RA11 is selected from —C(O)OH, (5-6 membered)heterocycloalkyl, halogen, cyano, nitro, —(C1-C4)alkyl, —N(RA12)2, —ORA12, —SRA12, —N(ORA12)RA12, —C(O)RA12, —C(O)ORA12, —C(O)N(RA12)2, —N(RA12)S(O)RA12, —N(RA12)S(O)2RA12, —S(O)N(RA12)2, —S(O)2N(RA12)2, —S(O)2RA12, —OC(O)RA12, —OC(O)ORA12, —OC(O)N(RA12)2, —N(RA12)C(O)RA12, —N(RA12)S(O)2RA12, —N(RA12)C(O)ORA12, —N(RA12)C(O)N(RA12)2, —N(RA12)C(═NRA12)N(RA12)2, and heteroaryl, wherein each RA12 is independently hydrogen, —(C1-C4)alkyl, or —(C1-C4)haloalkyl; and each R8 is independently hydrogen, halogen, or methyl, or both R8 taken together with the carbon to which they are both attached form either a (C3-C6)cycloalkyl or a (3-6 membered)heterocycloalkyl. ### Claim 2 (depends on 1) The compound according to claim 1 having structural formulae (VI): or pharmaceutically acceptable salt thereof, wherein: RA is —[C(CH3)2]-phenyl, —[C(CH3)2]-naphthalenyl, or —[C(CH3)2]-(5-10 membered)heteroaryl, wherein the heteroaryl is selected from (benzo[d][1,3]dioxolyl, benzo[d]isoxazole, quinoxalinyl, quinolinyl and 2,3,4a,8a-tetrahydrobenzo[b][1,4]dioxinyl, wherein the cyclic group of RA is optionally substituted with 1, 2 or 3 RA10, provided that substitution of the cyclic group of RA with RA10 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the cyclic group of RA; each RA10 is independently selected from halo, alkoxyl, hydroxyl, —(C1-C4)alkyl optionally substituted with 1-3 groups selected from —OH and halo, —NH2, —S(O)2—NH2, —S(O)2CH3, —N(H)—S(O)2CH3, —SO2N(H)—CH3, —CN, —C(O)OH, —(C1-C4)alkyl—OH, —OCF3, and —C(O)NH2; RC is phenyl, —CH2-phenyl, —(C5-C6)-cycloalkyl, or pyridinyl, wherein the cyclic group of RC can be optionally substituted with 1, 2 or 3 RC10, provided that substitution of the cyclic group of RC with RC10 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the cyclic group of RC, and wherein the 1, 2, or 3 RC10 groups are independently selected from RC10A and RC10B, provided that RC cannot be substituted with more than 1 RC10B group; each RC10A is independently selected from halo, and —(C1-C3)alkyl optionally substituted with 1-3 groups selected from —OH, methoxy, —CF3 and halo; RC10B is selected from —C(O)NH2, (5-6 membered)heterocycloalkyl, —O—(C1-C4)alkyl optionally substituted with —OH, —C(O)OH, or —N[—(C1-C4)alkyl]2, and —(C1-C4)alkyl substituted with —N[—(C1-C4)alkyl]2; RD is -LD-RD1; LD is —Y—[C(R)2]q—; q is 0 or 1; each R is independently selected from H, —(C1-C3)alkyl, halo, —OH, and —CH2OH; Y is a bond, —S—, —S(O)2—, —O—, —C(H)═C(H)—, —C(O)—(C1-C4)alkyl-, —(C1-C4)alkyl-S—(C1-C4)alkyl-, —(C1-C4)alkyl-N(RY)—(C1-C4)alkyl-, —C(H)(halo)-, —(C1-C4)alkyl-S(O)2—, —S(O)2—N(RY)—, —(C1-C4)alkyl-O—, —C(H)(OH)—, or —C(O)—N(RY)—, wherein RY is H, —(C1-C4)alkyl, hydroxyl(C1-C4)alkyl or —C≡C—(C1-C3)alkyl-; or RD is -LD-RD1; LD is —[C(R)2]p—Y—[C(R)2]q—; p is 0 or 1: q is 0 or 1; each R is independently selected from H, —(C1-C3)alkyl, halo, —OH, and —CH2OH; Y is a bond, —S—, —S(O)2—, —CH(OH)—, —O—, —C(H)═C(H)—, —C(O)—(C1-C4)alkyl-, —(C1-C4)alkyl-S—(C1-C4)alkyl-, —(C1-C4)alkyl-N(RY)—(C1-C4)alkyl-, —C(H)(halo)-, —(C1-C4)alkyl-S(O)2—, —S(O)2—N(RY)—, —(C1-C4)alkyl-O—, or —C(O)—N(RY)—, wherein RY is H, —(C1-C4)alkyl, hydroxyl(C1-C4)alkyl or —C≡C—(C1-C3)alkyl-; RD1 is selected from —(C6-C10)aryl, —N(H)-phenyl, cycloalkyl, heterocycloalkyl, and heteroaryl, wherein RD1 can be optionally substituted with 1, 2, 3, or 4 RD10, provided that substitution of RD1 with RD10 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of RD1, wherein the 1-4 RD10 groups are independently selected from A groups and B groups, provided that RD1 cannot be substituted with more than 2 B groups; each A group, when they occur, is independently selected from halo, —CF3, —CN, —NO2, —OH, —NH2, —O—(C1-C4)alkyl optionally substituted at the alkyl group with 1-3 substituents independently selected from —OH and halo, and —(C1-C4)alkyl optionally substituted with 1-3 substituents independently selected from —OH and halo; each B group, when they occur, is independently selected from —(C1-C4)alkylN(RD11)2, —C(O)—NH2, —C(O)—N(H)—OH, —C(O)—N(H)—RD11C, —C(O)—(C1-C4)alkyl, —C(O)OH, —C(O)O—(C1-C4)alkyl, —S(O)2—(C1-C4)alkyl-N(RD11)2, —S(O)2—N(RD11)RD11C, —S(O)2—N(H)C(O)—(C1-C4)alkyl, —S(O)2—N(H)C(O)O—(C1-C4)alkyl, —S(O)2—N(H)C(O)—N(RD11)RD11B, —S(O)2—(C1-C4)alkyl, —C(O)-heterocycloalkyl optionally substituted with RD11B, provided that substitution of the —C(O)-heterocycloalkyl with RD11B can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of —C(O)-heterocycloalkyl, —C(O)—N(H)—(C1-C6)alkyl optionally substituted at the alkyl group with 1 or 2 RD11B, heterocycloalkyl optionally substituted with oxo or RD11, provided that substitution of the heterocycloalkyl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the heterocycloalkyl, heterocycloalkenyl optionally substituted with oxo or RD11, provided that substitution of the heterocycloalkenyl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the heterocycloalkenyl, heteroaryl optionally substituted with RD11, provided that substitution of the heteroaryl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the heteroaryl, —O—(C1-C4)alkyl optionally substituted at the alkyl group with 1 or 2 RD11B, —S(O)2-(4-6 membered)heterocycloalkyl optionally substituted with RD11C, provided that substitution of the —S(O)2-(4-6 membered)heterocycloalkyl with RD11C can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the —S(O)2-(4-6 membered)heterocycloalkyl, —N(H)—C(O)—(C1-C4)alkyl optionally substituted at the alkyl group with 1 or 2 RD11B, —N(H)—C(O)—N(H)—(C1-C3)alkyl optionally substituted at the alkyl group with RD11B, —(C1-C6)alkyl optionally substituted with 1 or 2 RD11B, —C(═NH)—NH2, and —C≡C—(C1-C3)alkyl optionally substituted with RD11B; each RD11 is independently selected from H, —(C1-C4)haloalkyl, —(C3-C6)cycloalkyl, —OH, —(C1-C3)alkyl-phenyl optionally substituted at the phenyl group with 1-3 substituents selected from methoxy, hydroxyl and halo, and —(C1-C4)alkyl optionally substituted with halo, —C(O)OH, —OH, —S(O)2OH, C(O)OH, —NH2, or —N(H)C(═NH)NH2; RD11B is selected from H, —OH, —CF3, —NH2, —C(O)OH, —(CH2)1-4—C(O)OH, —O—(C1-C4)alkyl, —S(O)2OH, —C(═NH)—NH2, —N(H)C(═NH)NH2, —C(H)═NN(H)C(═NH)NH2, —N(H)C(═NH)—N(H)C(═NH)NH2, —C(O)—(C1-C3)alkyl, —O—(C1-C4)alkyl-C(O)OH, —(C3-C6)cycloalkyl, (5-6 membered)heteroaryl, —(C1-C4)alkyl optionally substituted with 1-3 groups independently selected from halo, —OH, —S(O)2OH, C(O)OH, —NH2, and —N(H)C(═NH)NH2, -(5-6 membered)heterocycloalkyl optionally substituted with 1, 2 or 3 RD11, provided that substitution of the -(5-6 membered)heterocycloalkyl with RD11 can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the -(5-6 membered)heterocycloalkyl, and aryl optionally substituted with 1-3 halo; or RD11 and RD11B, when they both exist and are each attached to nitrogen, can join together with the nitrogen to which they are attached to form a (5-6 membered) heterocycloalkyl optionally substituted with a group selected from —(C3-C6)cycloalkyl, —(C1-C4)haloalkyl, —OH, —S(O)2OH, C(O)OH, —NH2, —N(H)C(═NH)NH2, —(C1-C4)alkyl optionally substituted with halo, —OH or —C(O)OH, and —(C1-C3)alkyl-phenyl optionally substituted at the phenyl group with 1-3 substituents selected from methoxy, hydroxyl and halo, provided that substitution of the (5-6 membered) heterocycloalkyl can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the (5-6 membered) heterocycloalkyl; and RD11C is selected from H, —OH, —CF3, —O—(C1-C4)alkyl, —(C1-C4)alkyl-N(H)C(═NH)—NH2, —(C0-C3)alkyl-(5-6 membered)heteroaryl, —(C1-C4)alkyl optionally substituted with 1-3 groups independently selected from halo, —OH, —S(O)2OH, C(O)OH, —NH2, and —N(H)C(═NH)NH2, —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl optionally substituted with a -(5-6 membered)heteroaryl, provided that substitution of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl, —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl substituted 1, 2 or 3 groups selected from selected from —OH and —(C1-C3)alkyl, provided that substitution of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the —(C0-C3)alkyl-(5-6 membered)heterocycloalkyl, and —C0-C3)alkyl-aryl optionally substituted at the aryl group with 1-3 halo. ### Claim 3 (depends on 1) The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein: LD is selected from —(C1-C3)alkyl-O—, —(C0-C3)alkyl-NRY—(C0-C3)alkyl-, —(C0-C3)alkyl-S—(C0-C3)alkyl-, —(C0-C3)alkyl-S(O)2—(C0-C3)alkyl-; —C(O)N(RY)—(C0-C3)alkyl-, —S(O)2—N(RY)—(C0-C3)alkyl-, —C(O)—(C0-C3)alkyl-, —(C1-C4)alkyl-optionally substituted with halo or —OH, —C≡C—(C0-C3)alkyl-and —(C0-C3)alkyl-. ### Claim 4 (depends on 1) The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein the B group of RD1 is selected from: ### Claim 5 (depends on 1) The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein RC is phenyl, —CH2-phenyl, —(C5-C6)-cycloalkyl, or pyridinyl, wherein RC can be optionally substituted with 1, 2 or 3 RC10, provided that substitution of RC can only occur by replacing a hydrogen that is covalently bound to either a carbon or a nitrogen of the RC, and wherein the 1, 2 or 3 RC10 groups are independently selected from RC10A and RC10B, provided that RC cannot be substituted with more than 1 RC10B group; each RC10A, when they occur, is independently selected from —(C1-C3)alkyl optionally substituted with 1-3 groups selected from halo and —OH, methoxy, —CF3 and halo; and RC10B is selected from —C(O)NH2, (5-6 membered)heterocycloalkyl, —O—(C1-C4)alkyl optionally substituted with —OH, —C(O)OH, or —N[—(C1-C4)alkyl]2, and —(C1-C4)alkyl substituted with —N[—(C1-C4)alkyl]2. ### Claim 6 (depends on 1) The compound according to claim 1, or a pharmaceutically acceptable salt thereof, having formula IX, X, XI, XII, XIII, XIV or XV: ### Claim 7 (depends on 6) The compound according to claim 6, or a pharmaceutically acceptable salt thereof, wherein each RA10 is selected from fluoro, chloro and methoxy; each RC10 is selected from fluoro, chloro and methoxy; R2 is -LD-RD1, wherein: LD is selected from —(CH2)—O—, —(CH2)—NH—, —(CH2)—S—, —S—(CH2)—, —S(O)2—, —S(O)2—(CH2)—, —C(O)N(H)—(CH2)1-3—, —S(O)2—N(H)—(CH2)1-3—, —C(O)—(CH2)1-2—, —(C1-C3)alkyl-optionally substituted with halo or —OH, and —C≡C—(C2-C3)alkyl; and RD1 is one of: wherein each A is chloro or fluoro, and B is selected from: ### Claim 8 (depends on 1) The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R5 is —[C(CH3)2]-phenyl, —[C(CH3)2]-naphthalenyl, or —[C(CH3)2]-(5-10 membered) heteroaryl, wherein the heteroaryl is selected from (benzo[d][1,3]dioxolyl, benzo[d]isoxazole, quinoxalinyl, quinolinyl and 2,3,4a,8a-tetrahydrobenzo[b][1,4]dioxinyl, wherein the cyclic group of R5 is optionally substituted with one, two, or three RA10 groups, wherein the one, two, or three RA10 groups are independently selected from RA10A and RA10B, provided that R5 cannot be substituted with more than 1 RA10B group; and each RA10A, when they occur, is independently selected from halo, —(C1-C3)alkoxyl and hydroxyl; RA10B is —(C1-C4)alkyl optionally substituted with 1-3 groups selected from —OH and halo, —O—(C1-C4)alkyl-C(O)OH, O—(C1-C4)alkyl-N[(C1-C3)alkyl]2, —NH2, —S(O)2—NH2, —SO2CH3, —N(H)—SO2CH3, —SO2N(H)—CH3, —CN, —C(O)OH, —(C1-C4)alkyl-OH, —OCF3, or —C(O)NH2. ### Claim 9 (depends on 1) The compound according to claim 1, or a pharmaceutically acceptable salt thereof, wherein R5 is: ### Claim 10 (depends on 1) The compound according to claim 1 selected from one of the following compounds: 5-{[3,4-bis(methyloxy)phenyl]methyl}-2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(1,3-benzodioxol-5-yl)-1-methylethyl]-2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(1,3-benzodioxol-5-yl)-1-methylethyl]-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[(3,4-difluorophenyl)methyl]-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2,6-dichlorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2,4-dichlorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(3,4-dichlorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-2-({[2-fluoro-6-(trifluoromethyl)phenyl]methyl}thio)-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(3-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2-chloro-6-fluorophenyl)methyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2-chloro-5-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(3-chloro-5-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 4-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzene-1,2-diol; 4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzene-1,2-diol; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-5-{1-methyl-1-[4-(methyloxy)phenyl]ethyl}-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]sulfonyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{[1-(2-chloro-6-fluorophenyl)-1-methylethyl]sulfonyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-[(E)-2-(2-chloro-6-fluorophenyl)ethenyl]-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]sulfonyl}-5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-5-[1-(4-fluorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(4-chlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 4-chloro-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 5-{1- [3,4-bis(methyloxy)phenyl]-1-methylethyl}-4-chloro-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 2-[(4-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]-N,N-dimethylethanamine; N-{[5-{1- [3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]methyl}-2-chloro-6-fluoroaniline; N-{[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]methyl}-2-chloro-4-fluoroaniline; 3-(2,4-dichlorophenyl)-1-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}propan-1-ol; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-5-{1-methyl-1-[4-(trifluoromethyl)phenyl]ethyl}-1H-imidazole; 2-[(4-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]ethanol; [(4-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]acetic acid; 2-{[(2-chloro-4-fluorophenyl)methyl]sulfonyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{[(3-chloro-4-fluorophenyl)methyl]sulfonyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(3,4-dichlorophenyl)methyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 3-(2,4-dichlorophenyl)-1-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}propan-1-one; N-{[5-{1[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]methyl}-3-chloro-4-fluoroaniline; N-{[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]methyl}-3,4-dichloroaniline; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[2-(2-chloro-4-fluoropheny)ethyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[2-(3,4-dichlorophenyl)ethyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(3,4-difluorophenyl)methyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-2-({[4-fluoro-3-(trifluoromethyl)phenyl]methyl}sulfonyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(2,4-dichlorophenyl)methyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(2,6-dichlorophenyl)methyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(2,5-dichlorophenyl)methyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 4-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzenesulfonamide; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[2-(3-chloro-4-fluorophenyl)ethyl]sulfonyl}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]sulfonyl}-1-(4-chlorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]sulfonyl}-1-(3,4-dichlorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)thio]methyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(3,4-dichlorophenyl)thio]methyl}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]sulfonyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(2,4-difluorophenyl)-1H-imidazole; 1-(2-chloro-4-fluorophenyl)-2-{[(2-chloro-6-fluorophenyl)methyl]sulfonyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(3,4-dichlorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(2,4-difluorophenyl)-1H-imidazole; 1-(2-chloro-4-fluorophenyl)-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)oxy]methyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-({[(2-chloro-4-fluorophenyl)methyl]oxy}methyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; N-(4-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)methanesulfonamide; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2-chloro-6-fluorophenyl)oxy]methyl}-1-(4-fluorophenyl)-1H-imidazole; 1-(3-chloro-4-fluorophenyl)-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(2,4-dichlorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[(4-fluorophenyl)methyl]-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-N-cyclohexyl-1-(4-fluorophenyl)-1H-imidazole-2-carboxamide; 1-[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]-N-[(4-chloro-3-fluorophenyl)methyl]methanamine; 1-(4-chloro-3-fluorophenyl)-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3,4-difluorophenyl)-1H-imidazole; 1-(4-chloro-2-fluorophenyl)-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 5-[1-(4-chloro-3-fluorophenyl)-1-methylethyl]-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3,4-difluorophenyl)-1H-imidazole; 3-(2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-1-yl)pyridine; N-[(2-chloro-4-fluorophenyl)methyl]-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole-2-sulfonamide; N-(2-chloro-4-fluorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole-2-sulfonamide; 4-[4-(2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-1-yl)phenyl]morpholine; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-{[(2-chloro-6-fluorophenyl)thio]methyl}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-5-{1-methyl-1-[3-(methylsulfonyl)phenyl]ethyl}-1H-imidazole; 2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzamide; 2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzonitrile; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzonitrile; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-cyclopentyl-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazole; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorobenzoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorobenzamide; 2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzoic acid; 5-(2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-1-yl)-2-fluorobenzamide; 5-(2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-1-yl)-2-fluorobenzonitrile; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-2-(methyloxy)phenyl]-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3,5-difluorophenyl)-1H-imidazole; 2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzoic acid; 2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzenesulfonamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzoic acid; {5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}methanol; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzenesulfonamide; {2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorophenyl}methanol; 2-{2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorophenyl}propan-2-ol; 2-{[(2-chloro-4-fluorophenyl)sulfonyl]methyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}-N-methylbenzenesulfonamide; 4-{[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]carbonyl}morpholine; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-2-(pyrrolidin-1-ylcarbonyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-N-(3-chloro-4-fluorophenyl)-1-(4-fluorophenyl)-1H-imidazole-2-carboxamide; 5-[1-(3-chloro-4-fluorophenyl)-1-methylethyl]-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazole; {2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorophenyl}methanol; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-({[4-fluoro-2-(methylsulfonyl)phenyl]methyl}thio)-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-({[4-fluoro-3-(methylsulfonyl)phenyl]methyl}thio)-1-(4-fluorophenyl)-1H-imidazole; 3-chloro-2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzoic acid; 1-[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]-N-[(2-chloro-6-fluorophenyl)methyl]methanamine; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-N-[(1S)-2-hydroxy-1-phenylethyl]-1H-imidazole-2-sulfonamide; 5-[1-({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}sulfonyl)piperidin-2-yl]-2-(methyloxy)pyridine; N-[(2-chloro-6-fluorophenyl)methyl]-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole-2-sulfonamide; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-5-fluorophenyl)methyl]thio}-5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-{1[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazole; 2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzamide; 5-{2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}-1H-tetrazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[(3,4-dichlorophenyl)(difluoro)methyl]-1-(4-fluorophenyl)-1H-imidazole; 4-chloro-3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzonitrile; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzonitrile; 4-chloro-3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzamide; 5-[1-(4-chloro-2-fluorophenyl)-1-methylethyl]-2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-2-(trifluoromethyl)phenyl]-1H-imidazole; 2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzenesulfonamide; [5-(2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-1-yl)-2-fluorophenyl]methanol; 2-{[5-(2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-1-yl)-2-fluorophenyl]oxy}-2-methylpropanoic acid; {[5-(2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-1-yl)-2-fluorophenyl]oxy}acetic acid; ({5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}oxy)acetic acid; 2-({5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}oxy)-2-methylpropanoic acid; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-4-phenyl-1H-imidazole; 5-chloro-2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzoic acid; 4-chloro-3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluoro-N-(2-morpholin-4-ylethyl)benzamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluoro-N-[2-(methyloxy)ethyl]benzamide ; 2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorobenzoic acid; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzamide; 5-{4-chloro-3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}-1H-tetrazole; 5-{3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}-1H-tetrazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(2,6-dichlorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{[(2,6-difluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-2-{[(2,4,6-trifluorophenyl)methyl]thio}-1H-imidazole; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyllbenzoic acid; 4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorobenzoic acid; 5-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzoic acid; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-N-{[2-fluoro-4-(trifluoromethyl)phenyl]methyl}-1H-imidazole-2-sulfonamide; 2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzonitrile; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazole; N-({4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorophenyl}carbonyl)glycine; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluoro-N-(2-hydroxy-2-methylpropyl)benzamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluoro-N-(2,2,2-trifluoroethyl)benzamide; N-({5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}carbonyl)glycine; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluoro-N-(2-morpholin-4-ylethyl)benzamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluoro-N-(2-hydroxy-2-methylpropyl)benzamide; 4-({[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorobenzamide; 5-({[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzamide; 5-({[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzenesulfonamide; 2-({[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorobenzoic acid; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenecarboximidamide; 2-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzonitrile; 2-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzamide; 2-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzoic acid; 2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenecarboximidamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzonitrile; 1-({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}sulfonyl)-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline; 4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorobenzoic acid; 4-chloro-3-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzoic acid; 5-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-N-(2-chloro-6-fluorophenyl)-1-(4-fluorophenyl)-1H-imidazole-2-carboxamide; (2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)methanol; 2-(2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)propan-2-ol; ({2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorophenyl}oxy)acetic acid; 5-{5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}-1H-tetrazole; 2-{4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorophenyl}-2-methylpropanoic acid; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluoro-N-[2-(methyloxy)ethyl]benzamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluoro-N-(2,2,2-trifluoroethyl)benzamide; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-{1[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazole; 5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzenesulfonamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzamide; 4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzonitrile; 2-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenecarboximidamide; 5-{2-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}-1H-tetrazole; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-{1-[3,5-dichloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazole; 2-chloro-5-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)benzoic acid; 4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzoic acid; 5-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzoic acid; 5-{4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}-1H-tetrazole; 3-chloro-4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzoic acid; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-{1-[3,5-dichloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazole; 3-chloro-4-({[5-{1-[3,5-dichloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenesulfonamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorobenzenesulfonamide; 5-[2-chloro-5-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]-1H-tetrazole; 2-{[(2-chloro-4-fluorophenyl)methyl]thio}-5-(1-{3-chloro-4-[(trifluoromethyl)oxy]phenyl}-1-methylethyl)-1-(4-fluorophenyl)-1H-imidazole; 1-[(2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]-2-methylpropan-2-ol; [(2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]acetic acid; 2-[(2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]-2-methylpropanoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzoic acid; 2-{5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}-2-methylpropanoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluoro-N-[2-(1H-imidazol-4-yl)ethyl]benzamide; 2-[2-(2-chloro-6-fluorophenyl)ethyl]-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-2-[2-(2-chloro-6-fluorophenyl)ethyl]-1-(4-fluorophenyl)-1H-imidazole; 4-chloro-3-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)benzoic acid; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorobenzoic acid; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazole; 2-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]benzamide; 4-({[5-{1-[3,5-dichloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorobenzenesulfonamide; 5-({[5-{1-[3,5-dichloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzenesulfonamide; 2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenesulfonamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzenesulfonamide; 2,4-dichloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenesulfonamide; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-N-(2-chloro-4-fluorophenyl)-1-(4-fluorophenyl)-1H-imidazole-2-carboxamide; 1-({2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorophenyl}oxy)-2-methylpropan-2-ol; 2-({2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorophenyl}oxy)-2-methylpropanoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorobenzamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluoro-N-[2-(1H-imidazol-4-yl)ethyl]benzamide; 2-{2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}propan-2-ol; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzoic acid; 2-chloro-4-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzamide; 5-{4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorophenyl}-1H-tetrazole; 5-{4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}-1H-tetrazole; 5-[2,4-dichloro-5-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]-1H-tetrazole; 4-chloro-3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]benzoic acid; 5-{3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]phenyl}-2H-tetrazole; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-N-(3,4-dichlorophenyl)-1-(4-fluorophenyl)-1H-imidazole-2-carboxamide; 5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-N-[(4-chloro-3-fluorophenyl)methyl]-1-(4-fluorophenyl)-1H-imidazole-2-carboxamide; 1-({5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}oxy)-2-methylpropan-2-ol; 2-{3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-4-fluorophenyl}-2-methylpropanoic acid; 2-{4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorophenyl}propan-2-ol; 2-{3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}propan-2-ol; 2-{5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}propan-2-ol; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzoic acid; 5-[4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]-1H-tetrazole; 1-[(2-chloro-5-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]-2-methylpropan-2-ol; 4-{3-[(2-chloro-5-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]propyl}morpholine; 1-{5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}-4-methylpiperazine; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]piperidine; 5-[2-chloro-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]-1H-tetrazole; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(methylsulfonyl)piperidine; 2-chloro-5-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenol; 2-[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]propan-2-ol; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzoic acid; 4-[({5-[1-(4-chloro-3-hydroxyphenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 5-[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]-1H-tetrazole; 3-chloro-4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzoic acid; 2-[(2-chloro-5-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]-N,N-diethylethanamine; 4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 1,1-dimethylethyl 4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]piperidine-1-carboxylate; 4-{2-[(2-chloro-5-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]ethyl}morpholine; 5-{1[3,4-bis(methyloxy)phenyl]-1-methylethyl}-N-(2-chloro-6-fluorophenyl)-1-(4-fluorophenyl)-N-methyl-1H-imidazole-2-carboxamide; N-{[5-{1-[3,4-bis(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]methyl}-2-chloro-6-fluoro-N-methylaniline; 5-(2-chloro-5-{[(5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}phenyl)-1H-tetrazole; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-1-(methylsulfonyl)piperidine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]methyl}oxy)-5-fluorobenzoic acid; 2-chloro-5-{1-[2-{[(2-chloro-4-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzenesulfonamide; 1-{2-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}-4-methylpiperazine; 1-{4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}-4-methylpiperazine; 4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(methylsulfonyl)piperidine; 3-[(2-chloro-5-{1-[2-{[(2-chloro-6-fluorophenyl)methyl]thio}-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}phenyl)oxy]propan-1-ol; 5-[5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorophenyl]-1H-tetrazole; 3-chloro-4-({[5-(1-{4-chloro-3-[(3-morpholin-4-ylpropyl)oxy]phenyl}-1-methylethyl)-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzoic acid; 3-{4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]piperidin-1-yl}propane-1,2-diol; 2-[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)piperidin-1-yl]ethanol; [4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)piperidin-1-yl]acetic acid; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzoic acid; methyl 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]-5-fluorobenzoate; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3-{[2-(diethylamino)ethyl]oxy}-4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-5-fluorobenzoic acid; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]sulfonyl}methyl)-1-(methylsulfonyl)piperidine; 2-chloro-4-{1-[2-({[4-chloro-3-(1H-tetrazol-5-yl)phenyl]methyl}thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-5-fluorobenzoic acid; 4-({[5-{1-[3-(aminosulfonyl)-4-chlorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-5-fluorobenzoic acid; 2-chloro-5-{1-[2-({[4-chloro-3-(1H-tetrazol-5-yl)phenyl]methyl}thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzenesulfonamide; 2-({[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorophenyl]carbonyl}amino)ethanesulfonic acid; 3-chloro-4-{[(5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-{4-fluoro-3-[(3-hydroxypropyl)oxy]phenyl}-1H-imidazol-2-yl)thio]methyl}-5-fluorobenzoic acid; 5-[2-chloro-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]methyl}oxy)phenyl]-1H-tetrazole; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]-5-fluorobenzoic acid; 2-({4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-(1H-tetrazol-5-yl)phenyl}oxy)-N,N-diethylethanamine; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(4-fluorophenyl)piperidine; 2-({4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]piperidin-1-yl}sulfonyl)-N,N-diethylethanamine; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(1H-tetrazol-5-yl)piperidine; 1-acetyl-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]piperidine; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-[(3-hydroxypropyl)oxy]benzonitrile; 2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzoic acid; 4-({[5-{1-[3-(aminosulfonyl)-4-chlorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzoic acid; 3,5-difluoro-4-({[1-(4-fluorophenyl)-5-(1-methyl-1-naphthalen-2-ylethyl)-1H-imidazol-2-yl]thio}methyl)benzoic acid; 6-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]pyridine-3-carbonitrile; 6-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]pyridine-3-carboxamide; 1-{5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluorophenyl}guanidine; N-({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)-1-(methylsulfonyl)piperidin-4-amine; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]-1-(methylsulfonyl)piperidine; 3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(1H-tetrazol-5-yl)piperidine; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-1-(1H-tetrazol-5-yl)piperidine; 1,1-dimethylethyl 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]piperidine-1-carboxylate; 2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-4-methyl-1H-imidazole; ethyl 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-4-methyl-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzoate; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-4-methyl-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzoic acid; 3-chloro-4-{[(5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-pyridin-3-yl-1H-imidazol-2-yl)thio]methyl}-5-fluorobenzoic acid; 3-(2-{[(2-chloro-6-fluorophenyl)methyl]thio}-5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1H-imidazol-1-yl)pyridine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzoic acid; ({2-(aminosulfonyl)-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}oxy)acetic acid; 2-chloro-N-({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)-6-fluoro-N-methylaniline; 4-[({4-chloro-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(methylsulfonyl)piperidine; 1,1-dimethylethyl 3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]pyrrolidine-1-carboxylate; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-{[2-(diethylamino)ethyl]oxy}benzenesulfonamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluoro-N-hydroxybenzamide; 4-[({5-[1-(3-cyano-4-fluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 5-chloro-2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]pyridine; 6-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]pyridine-3-carboxylic acid; 2-[({4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-fluorophenyl}carbonyl)amino]ethanesulfonic acid-sodium (1:1); 3,5-difluoro-4-{[(1-[4-fluoro-3-(methyloxy)phenyl]-5-{1-methyl-1-[3-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl)thio]methyl}benzoic acid; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-fluoro-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; N-({3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}sulfonyl)acetamide; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1,2-bis(4-fluorophenyl)-1H-imidazole; 2-{[(2-chloro-6-fluorophenyl)oxy]methyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-2-[{[1-(methylsulfonyl)pyrrolidin-3-yl]methyl}thio)-1H-imidazole; 5-{3-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]pyrrolidin-1-yl}-1H-tetrazole; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-N-(1-methylethyl)piperidine-1-carboxamide; N-[(4-chloro-2-fluorophenyl)methyl]-5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-amine; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-[({5-[1-(3,4-dichlorophenyl)cyclopropyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 3-chloro-2-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]-5-(trifluoromethyl)pyridine; 3,5-difluoro-4-{[(1-[4-fluoro-3-(methyloxy)phenyl]-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl)thio]methyl}benzoic acid; 4-{[(5-{1-[4-(aminosulfonyl)phenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3,5-difluorobenzoic acid; 2-{1-[(2-chloro-4-fluorophenyl)thio]ethyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 2-{1-[(2-chloro-4-fluorophenyl)sulfonyl]ethyl}-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazole; 4-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}-1-(methylsulfonyl)-1,2,3,6-tetrahydropyridine; 4-({[4-chloro-5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-1-(methylsulfonyl)piperidine; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-1-(1H-tetrazol-5-yl)piperidine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 4-(2-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}-2-fluoroethyl)-1-(methylsulfonyl)piperidine; 5-[1-(3,4-dichlorophenyl)-1-methylethyl]-2-{1-[(3,4-dichlorophenyl)oxy]ethyl}-1-(4-fluorophenyl)-1H-imidazole; 2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide 4-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}-1-(methylsulfonyl)piperidine; 4-({[4-chloro-5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-1-(1H-tetrazol-5-yl)piperidine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}oxy)methyl]-1-(1H-tetrazol-5-yl)piperidine; 4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-pyrrolidin-1-ylpiperidine-1-carboxamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-[(2-hydroxy-2-methylpropyl)oxy]benzenesulfonamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-[(2-oxopropyl)oxy]benzenesulfonamide; 6-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]quinoline; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]quinoline; 1-{3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}methyl)oxy]phenyl}ethanone; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluoro-N-hydroxybenzamide; ethyl{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]sulfonyl}carbamate; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(propylamino)carbonyl]benzenesulfonamide; 4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-(1-methylethyl)piperidine-1-carboxamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenesulfonamide; 3-chloro-4-[({5-[1(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; ethyl ({3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]phenyl}sulfonyl)carbamate; 3-chloro-4-[({5-[1(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 5-{2-chloro-5-[({1-(3-chlorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]phenyl}-1H-tetrazole; 5-{2-chloro-4-[({4-chloro-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}-1H-tetrazole; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 4-[({5-[1(3,4-dichlorophenyl)-1-methylethyl]-1-[3-(difluoromethyl)-4-fluorophenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluoro-N-hydroxybenzamide; 4-[({5-[1-(3-cyano-4-fluorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 4-[({5-[1-(3-amino-1,2-benzisoxazol-5-yl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3,4-difluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(1H-tetrazol-5-yl)piperidine; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3,4-difluorophenyl)-1H-imidazol-2-yl}thio)methyl]-1-(methylsulfonyl)piperidine; 5-{2-chloro-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]phenyl}-1H-tetrazole; 4-[({1-(3-chloro-4-fluorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-1-(methylsulfonyl)piperidine; ethyl {[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorophenyl]sulfonyl}carbamate; ethyl {[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorophenyl]sulfonyl}carbamate; 3-chloro-4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)benzenesulfonamide; 3-chloro-4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; ethyl {[3-chloro-4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]sulfonyl}carbamate; 3-chloro-4-(2-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}ethyl)benzenesulfonamide; 4-[({1-(3-chloro-4-fluorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-1-(1H-tetrazol-5-yl)piperidine; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 3-chloro-4-(2-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}ethyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; ethyl [(4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3-chlorophenyl)sulfonyl]carbamate; ({[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorophenyl]carbonyl}amino)methanesulfonic acid; N-{[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluorophenyl]carbonyl}-beta-alanine; 4-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}-N-pyrrolidin-1-ylpiperidine-1-carboxamide; 5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-2-[(2-hydroxyethyl)oxy]benzenesulfonamide; 4-[({5-[1-(3-amino-1,2-benzisoxazol-5-yl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3,5-difluorobenzoic acid; 3,5-difluoro-4-({[1-(4-fluorophenyl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)benzoic acid; 2-chloro-4-(1-{2-({[4-chloro-3-(1H-tetrazol-5-yl)phenyl]methyl}thio)-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-5-yl}-1-methylethyl)benzenesulfonamide; ethyl {[4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chlorophenyl]sulfonyl}carbamate; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(ethylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-{[(2-hydroxy-2-methylpropyl)amino]carbonyl}benzenesulfonamide; [({4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[-4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}carbonyl)amino]methanesulfonic acid; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-fluoro-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-(2-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}ethyl)-5-fluorobenzoic acid; 3-chloro-4-{[(5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}benzenesulfonamide; N-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]sulfonyl}pyrrolidine-1-carboxamide; 3-chloro-4-{[(5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(hydroxymethyl)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorobenzoic acid; 4-({[1-(3,4-difluorophenyl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzoic acid; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(cyclopropylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(cyclopentylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({1-(3,4-difluorophenyl)-5-[1-(3,4-difluorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({1-(3-chloro-4-fluorophenyl)-5-[1-(3,4-difluorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 2-[({4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}carbonyl)amino]ethanesulfonic acid; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluoro-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[1-(3-chloro-4-fluorophenyl)-5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(3,4-difluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; N-({4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}carbonyl)-beta-alanine; N-[({[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]sulfonyl}amino)carbonyl]-beta-alanine; 3-chloro-4-[({1-[4-fluoro-3-(methyloxy)phenyl]-5-[1-(4-fluorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-(1-{2-({[4-(aminosulfonyl)-2-chlorophenyl]methyl}thio)-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-5-yl}-1-methylethyl)-2-chlorobenzenesulfonamide; 4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3-chloro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(3,4-difluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluoro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[1-(4-fluoro-3-methylphenyl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-{[(1-[4-fluoro-3-(methyloxy)phenyl]-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl)thio]methyl}-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[1-(5-fluoropyridin-2-yl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(2,4-difluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({1-(3,4-difluorophenyl)-5-[1-(4-fluorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[1-(4-fluorophenyl)-5-{1-methyl-1[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({1-(3-chloro-4-fluorophenyl)-5-[1-(4-fluorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(3,4-difluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzoic acid; 2-chloro-4-{1-[2-({[4-chloro-3-(1H-tetrazol-5-yl)phenyl]methyl}thio)-1-(3,4-difluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}benzenesulfonamide; 5-[2-chloro-5-({[1-(4-fluorophenyl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)phenyl]-1H-tetrazole; 2-({[3-chloro-4-(2-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}ethyl)-5-fluorophenyl]carbonyl}amino)ethanesulfonic acid; 3-chloro-4-({[1-(3,4-difluorophenyl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(4-chlorophenyl)-1-methylethyl]-1-(2,4-difluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-difluorophenyl)-1-methylethyl]-1-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(3-chloro-4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3,5-difluoro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluoro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[3-chloro-4-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(3,5-difluoropyridin-2-yl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(3,5-difluoropyridin-2-yl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]benzenesulfonic acid; 4-({[5-{1-[4-(aminosulfonyl)phenyl]-1-methylethyl}-1-(3,4-difluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({1-(2,4-difluorophenyl)-5-[1-(3,4-difluorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)phenyl]-1-methylethyl}-1-(3-chloro-4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-N-[(morpholin-4-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[3-(difluoromethyl)-4-fluorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 3-chloro-4-({[5-{1-[4-(difluoromethyl)-3-fluorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-(5-fluoropyridin-2-yl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzoic acid; 3,5-difluoro-4-({[1-(5-fluoropyridin-2-yl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)benzoic acid; 5-(2-chloro-5-{[(1-[4-fluoro-3-(methyloxy)phenyl]-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl)thio]methyl}phenyl)-1H-tetrazole; 5-[2-chloro-5-({[1-(3,4-difluorophenyl)-5-{1-methyl-1-[4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)phenyl]-1H-tetrazole; 3-chloro-4-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluoro-3-methylphenyl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(1H-pyrrol-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[({(2R)-2-[(methyloxy)methyl]pyrrolidin-1-yl}amino)carbonyl]benzenesulfonamide; N-2-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}-L-arginine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(5-chloro-4-methylpyridin-2-yl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-{[(5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-[4-fluoro-3-(hydroxymethyl)phenyl]-1H-imidazol-2-yl)thio]methyl}-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; ({[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}amino)methanesulfonic acid; 3-chloro-4-[({1-(4-fluoro-3-methylphenyl)-5-[1-(4-fluorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; N-[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]-L-alpha-asparagine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-{[(4-methylpiperazin-1-yl)amino]carbonyl}benzenesulfonamide; 2-({[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}amino)ethanesulfonic acid; 4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3-chloro-N-[(piperidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[({(2S)-2-[(methyloxy)methyl]pyrrolidin-1-yl}amino)carbonyl]benzenesulfonamide; N-[(4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3,5-difluorophenyl)carbonyl]-beta-alanine; N-[(4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3-fluorophenyl)carbonyl]-beta-alanine; 2-({[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]carbonyl}amino)ethanesulfonic acid; [({4-[({1-(3-chloro-4-fluorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}carbonyl)amino]methanesulfonic acid; 2-[({4-[({1-(3-chloro-4-fluorophenyl)-5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}carbonyl)amino]ethanesulfonic acid; ({[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]carbonyl}amino)methanesulfonic acid; N-5-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}-L-ornithine; 2-{[(4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3,5-difluorophenyl)carbonyl]amino}ethanesulfonic acid; 2-{[(4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3-fluorophenyl)carbonyl]amino}ethanesulfonic acid; N-2-{[3-chloro-4-(2-{5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}ethyl)-5-fluorophenyl]carbonyl}-L-arginine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(1,3-thiazol-2-ylamino)carbonyl]benzenesulfonamide; N-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]sulfonyl}-3-hydroxypyrrolidine-1-carboxamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluoroaniline; N-[({[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]sulfonyl}amino)carbonyl]glycine; 3-chloro-4-({[5-{1-[3-(difluoromethyl)-4-fluorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-(difluoromethyl)-3-fluorophenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 2-chloro-4-{1-[2-({[2-chloro-4-({[(pyrrolidin-1-ylamino)carbonyl]amino}sulfonyl)phenyl]methyl}thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}-N-methylbenzenesulfonamide; N-2-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}-L-ornithine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(5-fluoro-4-methylpyridin-2-yl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; N-2-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}-D-arginine; 3-chloro-4-[({5-[1-(3-cyano-4-fluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-[({5-[1-(3-cyano-4-fluorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-{[(5-{1-[3-chloro-4-(methylsulfonyl)phenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; methyl 2-(3-{[amino(imino)methyl]amino}prop-1-yn-1-yl)-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]benzoate; N-2-({[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]amino}carbonyl)-L-arginine; 2-(3-{[amino(imino)methyl]amino}prop-1-yn-1-yl)-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]benzoic acid; 2-(3-{[amino(imino)methyl]amino}propyl)-5-[({5-[1-(3,4-dichlorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]benzoic acid; N-6-[amino(imino)methyl]-N-2-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}-L-lysine; 3-chloro-4-[({5-[1-(3-cyano-4-fluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 3-chloro-4-[({5-[1-(3-cyano-4-fluorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-N-{[(1-methylethyl)amino]carbonyl}benzenesulfonamide; 3-chloro-4-[({5-[1-(3-chloro-4-fluorophenyl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 3-chloro-4-({[5-{1-[4-fluoro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; N-2-[amino(imino)methyl]-N-5-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}-L-ornithine; 1-{3-[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]prop-2-yn-1-yl}guanidine; 2-(3-{[amino(imino)methyl]amino}propyl)-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)benzoic acid; 1-{3-[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]propyl}guanidine; 2-(3-{[amino(imino)methyl]amino}prop-1-yn-1-yl)-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)benzoic acid; 3-chloro-4-({[1-(4-fluorophenyl)-5-{1-methyl-1-[3-(methyloxy)-4-(methylsulfonyl)phenyl]ethyl}-1H-imidazol-2-yl]thio}methyl)-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-({[5-{1-[4-(aminosulfonyl)-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3-chloro-N-[(pyrrolidin-1-ylamino)carbonyl]benzenesulfonamide; 4-{1-[2-({[2-chloro-4-({[(pyrrolidin-1-ylamino)carbonyl]amino}sulfonyl)phenyl]methyl}thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl]-1-methylethyl}-N-methyl-2-(methyloxy)benzenesulfonamide; 1-{4-[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]butyl}guanidine; 1-{5-[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]pentyl}guanidine; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzenesulfonamide; N-(3-{[amino(imino)methyl]amino}propyl)-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorobenzenesulfonamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluoro-N-[1-(1H-tetrazol-5-yl)piperidin-4-yl]benzamide; N-(3-{[amino(imino)methyl]amino}propyl)-3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzamide; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluoro-N-1H-tetrazol-5-ylbenzamide; N-2-{[3-chloro-5-fluoro-4-({[5-{1-[4-fluoro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]carbonyl}-D-arginine; 4-({[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]carbonyl}amino)butanoic acid; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-N-[(1H-tetrazol-5-ylamino)carbonyl]benzenesulfonamide; 1-(2-{[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]oxy}ethyl)guanidine; 4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)pyridin-2-amine; 5-[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]-1,3,4-oxadiazol-2(3H)-one; N-2-({4-[({5-[1-(3-amino-1,2-benzisoxazol-5-yl)-1-methylethyl]-1-(4-fluorophenyl)-1H-imidazol-2-yl}thio)methyl]-3-chloro-5-fluorophenyl}carbonyl)-D-arginine; 3-[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]-1,2,4-oxadiazol-5(4H)-one; 5-({[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]oxy}methyl)-1H-tetrazole; N-2-[(4-{[(5-{1-[4-(aminosulfonyl)-3-chlorophenyl]-1-methylethyl}-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl)thio]methyl}-3-chloro-5-fluorophenyl)carbonyl]-D-arginine N-2-({4-[({5-[1-(3-amino-1,2-benzisoxazol-5-yl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3-chloro-5-fluorophenyl}carbonyl)-D-arginine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorobenzenesulfonic acid; 3-{4-[({5-[1-(3-chloro-4-fluorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}-N,N-dimethylpropan-1-amine; 2-chloro-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)benzenesulfonamide; 2-({[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]sulfonyl}amino)ethanesulfonic acid; 2-({[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]sulfonyl}amino)ethanesulfonic acid; 1-(3-{[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]oxy}propyl)guanidine; 1-(2-{[3,5-difluoro-4-({[5-{1-[4-fluoro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]oxy}ethyl)guanidine; 4-chloro-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2-fluorobenzenesulfonamide; 1-(3-{[3,5-difluoro-4-({[5-{1-[4-fluoro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]oxy}propyl)guanidine; 2-chloro-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-4-fluorobenzenesulfonamide; 1-(2-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]oxy}ethyl)guanidine; 1-(2-{[2-chloro-5-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-4-fluorophenyl]oxy}ethyl)guanidine; 3-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-2,4-difluorobenzenesulfonamide; 1-[2-({4-[({5-[1-(3-chloro-4-fluorophenyl)-1-methylethyl]-1-[4-fluoro-3-(methyloxy)phenyl]-1H-imidazol-2-yl}thio)methyl]-3,5-difluorophenyl}oxy)ethyl]guanidine; (2E)-2-(3-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]oxy}propylidene)hydrazinecarboximidamide; 1-(2-{[3-chloro-5-fluoro-4-({[5-{1-[4-fluoro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]oxy}ethyl)guanidine; 1-(3-{[3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluorophenyl]oxy}propyl)guanidine; 1-(3-{[3-chloro-5-fluoro-4-({[5-{1-[4-fluoro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]oxy}propyl)guanidine; 3-chloro-4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-5-fluoro-N-3,6,9,12,15,18,21,24,27,30,33,36,39,42-tetradecaoxatritetracont-1-ylbenzenesulfonamide; N-(2-{[4-({[5-{1-[4-chloro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)-3,5-difluorophenyl]oxy}ethyl)imidodicarbonimidic diamide; and 1-(3-{[2-chloro-4-fluoro-3-({[5-{1-[4-fluoro-3-(methyloxy)phenyl]-1-methylethyl}-1-(4-fluorophenyl)-1H-imidazol-2-yl]thio}methyl)phenyl]oxy}propyl)guanidine, or a pharmaceutically acceptable salt of any of the above compounds. ### Claim 11 (depends on 1) A composition comprising a compound according to claim 1 and a pharmaceutically acceptable diluent, excipient, or carrier. ### Claim 12 (depends on 1) A method for treating obesity, hyperlipidemia, athersclerosis or type II diabetes, or for lowering blood glucose or enhancing insuling secretion, in a subject in need of such treatment, comprising administering to the subject an effective amount of a compound of claim 1. ### Claim 13 (depends on 1) A method for treating obesity or type II diabetes in a subject in need of such treatment comprising co-administering to the subject, simultaneously or sequentially, an effective amount of a compound according to claim 1 and a second anti-diabetic drug. ### Claim 14 (depends on 1) A method for inducing increased GLP-1 secretion in cell, in vitro, comprising contacting the cell with an inducing effective amount of a compound of claim 1.