# US 8,785,481 B2 · Ether benzotriazole derivatives

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,785,481 B2
- Document ID: US8785481B2
- Status: Granted
- Kind: B2
- Application number: 13/247,009
- Filed: 2011-09-28
- Published: 2012-05-31
- Granted: 2014-07-22
- Earliest claimed: 2010-09-29
- Assignees: Merck Sharp & Dohme Corp.
- Applicants: Douglas C. Beshore; Vadim Dudkin; Robert M. Garbaccio; Adam W. Johnson; Scott D. Kuduk; Jason W. Skudlarek; Cheng Wang; Mark E. Fraley
- Inventors: Douglas C. Beshore; Vadim Dudkin; Robert M. Garbaccio; Adam W. Johnson; Scott D. Kuduk; Jason W. Skudlarek; Cheng Wang; Mark E. Fraley
- Web page: https://patentgrep.com/patent/US8785481B2

## CPC

- C07D 249/18: Benzotriazoles
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07D 413/12: linked by a chain containing hetero atoms as chain links
- C07D 417/12: linked by a chain containing hetero atoms as chain links
- C07D 471/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

## Claims

### Claim 1

A compound according to Formula I
or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of:
(1) C2-8alkyl,
(2) C2-8alkenyl,
(3) C2-8alkynyl,
(4) C3-6cycloalkyl-(CH2)p—, wherein p is 1, 2, 3 or 4, and
(5) benzyl, wherein groups (1) to (5) above are optionally substituted with 1 to 3 Ra groups;
each Ra and R2 is independently selected from the group consisting of: halo, OH, C1-4alkyl, C1-4alkoxy, CF3, —OCF3 and —CN;
Y is halo, CN or CF3;
X is C1-8alkyl, C3-8cycloalkyl, C2-8alkenyl or C2-8alkynyl, any of which is optionally substituted with up to 4 substituents selected from R3, said C3-8cycloalkyl further optionally substituted with 1 or 2 oxo groups and said C1-8alkyl further optionally substituted with ═N—OH;
each R3 is independently selected from the group consisting of: halogen, OH, CN, CF3, R5, OR5, SR5, SOR5, SO2R5, SO2N(R4)2, COR4, CO2R5, CON(R4)2, CON(R4)OR5, N(R4)2, NO2, NR4COR5, NR4CO2R5, NR4—C1-4alkyl-CO2R5, —C1-4alkyl-N(R4)2, —C1-4alkyl-NR4COR5 and —C1-4alkyl-NR4CO2R5;
each R4 independently represents: (1) H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, C3-10cycloalkenyl or C3-10cycloalkenylC1-4-alkyl, any of which except H optionally bear up to 5 halogen atoms or OH, CN, CF3 and C1-4alkoxy; (2) phenyl, benzyl or heteroaryl, optionally bridged with a methylene, any of which optionally bear up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino; and (3) Het, optionally bridged with a methylene and said Het optionally bearing up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino;
or when two R4 group are attached to the same nitrogen atom, they may be joined together with said nitrogen atom to form a non-aromatic monocyclic, a non-aromatic or partially aromatic bicyclic or a non-aromatic spiro-linked heterocyclic system of up to 12 ring atoms which optionally bears up to 4 substitutents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, C1-4alkylamino and di(C1-4alkyl)amino;
R5 has the same definition as R4 except that R5 is not H;
each “heteroaryl” independently refers to 5- or 6-membered aromatic monocyclic or 9- or 10-membered aromatic bicyclic ring systems, in which at least one ring atom is selected from N or N-oxide, O and S, excluding tetrazolyl; and
each “Het” independently refers to nonaromatic or partially aromatic mono- or bicyclic heterocyclic systems of up to 10 ring atoms, in which at least one ring atom is selected from N, O and S, where the sulfur atom may be in the form of the S-oxide or S,S-dioxide.

### Claim 2 (depends on 1)

The compound according to claim 1 wherein R3 is selected from the group consisting of: halogen, C1-4alkanoyl, hydroxy, ═N—OH, carboxy C1-6alkyl ester, acetate ester, C1-6alkoxy, —CON(H or C1-4alkyl)OH, —CON(H or C1-4alkyl)2, C1-4alkyl-CO2—C1-4alkyl-N(H or C1-4alkyl)-, C1-4alkyl-O—C(O)—N(H or C1-4alkyl)-, C1-6alkylthio, C1-6alkylsulfinyl, C1-6alkylsulfonyl and cyclopropyloxy.

### Claim 3

A compound according to Formula I
or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of:
(1) C2-8alkyl,
(2) C2-8alkenyl,
(3) C2-8alkynyl,
(4) C3-6cycloalkyl-(CH2)p—, wherein p is 1, 2, 3 or 4, and
(5) benzyl, wherein groups (1) to (5) above are optionally substituted with 1 to 3 Ra groups;
each Ra and R2 is independently selected from the group consisting of: halo, OH, C1-4alkyl, C1-4alkoxy, CF3, —OCF3 and —CN;
Y is halo, CN or CF3;
X is benzyl, benzoylmethyl, heteroaryl-methyl-, heteroaryl-ethyl- or heteroaryl -propyl-, any of which is optionally substituted with up to 4 substituents selected from R3;
each R3 is independently selected from the group consisting of: halogen, OH, CN, CF3, R5, OR5, SR5, SOR5, SO2R5, SO2N(R4)2, COR4, CO2R5, CON(R4)2, CON(R4)OR5, N(R4)2, NO2, NR4COR5, NR4CO2R5, NR4—C1-4alkyl-CO2R5, —C1-4 alkyl-N(R4)2, —C1-4-alkyl-NR4COR5 and —C1-4alkyl-NR4CO2R5;
each R4 independently represents: (1) H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, C3-10cycloalkenyl or C3-10cycloalkenylC1-4alkyl, any of which except H optionally bear up to 5 halogen atoms or OH, CN, CF3 and C1-4alkoxy; (2) phenyl, benzyl or heteroaryl, optionally bridged with a methylene, any of which optionally bear up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino; and (3) Het, optionally bridged with a methylene and said Het optionally bearing up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino;
or when two R4 group are attached to the same nitrogen atom, they may be joined together with said nitrogen atom to form a non-aromatic monocyclic, a non-aromatic or partially aromatic bicyclic or a non-aromatic spiro-linked heterocyclic system of up to 12 ring atoms which optionally bears up to 4 substitutents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, C1-4alkylamino and di(C1-4alkyl)amino;
R5 has the same definition as R4 except that R5 is not H;
each “heteroaryl” independently refers to 5- or 6-membered aromatic monocyclic or 9- or 10-membered aromatic bicyclic ring systems, in which at least one ring atom is selected from N or N-oxide, O and S, excluding tetrazolyl; and
each “Het” independently refers to nonaromatic or partially aromatic mono- or bicyclic heterocyclic systems of up to 10 ring atoms, in which at least one ring atom is selected from N, O and S, where the sulfur atom may be in the form of the S-oxide or S,S-dioxide.

### Claim 4 (depends on 3)

The compound according to claim 3 wherein R2 is not present and heteroaryl in X is selected from the group consisting of: pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyrazolo[1,5-a]pyridin-7-yl, imidazo[1,2-a]pyrimidin-2-yl, imidazo[1,2-a]pyridin-3-yl, triazolyl, benzotriazolyl, imidazolyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, oxadiazolyl, pyrazolyl, thiophenyl, furanyl, any of which is optionally substituted with up to 4 substituents selected from R3, and the methyl, ethyl or propyl linking groups of X are optionally substituted with hydroxy or methyl.

### Claim 5 (depends on 4)

The compound according to claim 4 wherein R3 is selected from the group consisting of: (1) halogen, (2) OH, (3) CN, (4) CF3, (5) methyl, (6) methoxy, (7) ethyl, (8) propyl, (9) cyclopropyl, (10) carboxy methyl ester, (11) nitro, (12) amino, (13) hydroxymethyl, (14) piperidinyl, (15) 2,2-dimethylpropanamino, (16) phenyl or benzyl, each of which may optionally bear up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, carboxy or a C1-4alkyl ester thereof, amino, carbamoyl, C1-4alkylamino and di(C1-4alkyl)amino; (17) pyridyl, which optionally bears up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, carboxy or a C1-4alkyl ester thereof, amino, carbamoyl, C1 -4alkylamino and di(C1-4alkyl)amino; (18) pyrimidinyl, which optionally bears up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, carboxy or a C1-4alkyl ester thereof, amino, carbamoyl, C1-4alkylamino and di(C1-4alkyl)amino, (19) pyrazolyl, (20) 2,2-dimethylpropanoylamino, (21) acetamino and (22) trifluoromethoxy.

### Claim 6

A compound according to Formula I
or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from the group consisting of:
(1) C2-8alkyl,
(2) C2-8alkenyl,
(3) C2-8alkynyl,
(4) C3-6cycloalkyl-(CH2)p—, wherein p is 1, 2, 3 or 4, and
(5) benzyl, wherein groups (1) to (5) above are optionally substituted with 1 to 3 Ra groups;
each Ra and R2 is independently selected from the group consisting of: halo, OH, C1-4alkyl, C1-4alkoxy, CF3, —OCF3 and —CN;
Y is halo, CN or CF3;
X is Het, Het-methyl-, Het-ethyl- or Het-propyl-, any of which is optionally substituted with up to 4 substituents selected from R3, the Het portions thereof further optionally substituted with 1 or 2 oxo groups;
each R3 is independently selected from the group consisting of: halogen, OH, CN, CF3, R5, OR5, SR5, SOR5, SO2R5, SO2N(R4)2, COR4, CO2R5, CON(R4)2, CON(R4)OR5, N(R4)2, NO2, NR4COR5, NR4CO2R5, NR4—C1-4alkyl-CO2R5, —C1-4alkyl-N(R4)2, —C1-4alkyl-NR4COR5 and —C1-4alkyl-NR4CO2R5;
each R4 independently represents: (1) H, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, C3-10cycloalkenyl or C3-10cycloalkenylC1-4alkyl, any of which except H optionally bear up to 5 halogen atoms or OH, CN, CF3 and C1-4alkoxy; (2) phenyl, benzyl or heteroaryl, optionally bridged with a methylene, any of which optionally bear up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino; and (3) Het, optionally bridged with a methylene and said Het optionally bearing up to 3 substituents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C1-4hydroxyalkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, carbamoyl, CO2—C1-4alkyl, C1-4alkylamino and di(C1-4alkyl)amino;
or when two R4 group are attached to the same nitrogen atom, they may be joined together with said nitrogen atom to form a non-aromatic monocyclic, a non-aromatic or partially aromatic bicyclic or a non-aromatic spiro-linked heterocyclic system of up to 12 ring atoms which optionally bears up to 4 substitutents independently selected from halogen, OH, oxo, CN, CF3, C1-4alkyl, C3-6cycloalkyl, phenyl, heteroaryl, C1-4alkoxy, acetyl, amino, C1-4alkylamino and di(C1-4alkyl)amino;
R5 has the same definition as R4 except that R5 is not H;
each “heteroaryl” independently refers to 5- or 6-membered aromatic monocyclic or 9- or 10-membered aromatic bicyclic ring systems, in which at least one ring atom is selected from N or N-oxide, O and S, excluding tetrazolyl; and
each “Het” independently refers to nonaromatic or partially aromatic mono- or bicyclic heterocyclic systems of up to 10 ring atoms, in which at least one ring atom is selected from N, O and S, where the sulfur atom may be in the form of the S-oxide or S,S-dioxide.

### Claim 7 (depends on 6)

The compound according to claim 6 wherein R2 is not present and Het in X is selected from the group consisting of: piperidine, oxazolidine, imidazolidine, thiazolidine, morpholine, thiomorpholine, pyrrolidine, piperazine, azepane, diazepane, azetidine, dioxolane, dioxane, oxetane, tetrahydropyran and tetrahydrofuran, any of which is optionally substituted with up to 4 substituents selected from R3 and further optionally substituted with one or two oxo groups, and the methyl, ethyl or propyl linking groups of X are optionally substituted with hydroxy or methyl.

### Claim 8 (depends on 7)

The compound according to claim 7 wherein R3 is selected from the group consisting of: (1) hydroxy, (2) fluoro, (3) carboxy C1-4alkyl ester, (4) C1-6alkyl optionally bearing up to 5 fluoro atoms; (5) C1-4alkoxy, (6) C1-4alkanoyl optionally bearing up to 5 fluoro atoms, methoxy or cyano, (7) cyclopropylcarbonyl, (8) C1-4alkylsulfonyl optionally bearing up to 5 fluoro atoms, (10) benzyloxycarbonyl, (11) benzoyl, (12) phenylsulfonyl, (13) C2-4alkenyl, (14) cyano, (15) phenyl and (16) pyridyl.

### Claim 9

A compound selected from the following group:
4-bromo-1-(2,2-dimethylpropyl)-5-methoxy-1H-1,2,3-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-ol;
4-bromo-1-(cyclopentylmethyl)-5-methoxy-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-ethoxy-1H-benzotriazole;
4-bromo-1-(cyclohexylmethyl)-5-methoxy-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-methoxy-1H-benzotriazole;
4-bromo-1-butyl-5-methoxy-1H-benzotriazole;
4-chloro-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-ol;
4-chloro-1-(2,2-dimethylpropyl)-5-methoxy-1H-benzotriazole;
4-bromo-1-(4,4,4-trifluorobutyl)-1H-benzotriazol-5-ol;
4-bromo-5-methoxy-1-(4,4,4-trifluorobutyl)-1H-benzotriazole;
4-bromo-1-[(3,3-difluorocyclobutyl)methyl]-5-methoxy-1H-benzotriazole;
5-(benzyloxy)-4-bromo-1-[(3,3-difluoro cyclobutyl)methyl]-1H-benzotriazole;
4,6-dibromo-1-(4,4,4-trifluorobutyl)-1H-benzotriazol-5-ol;
4,6-dibromo-1-[(1R)-1,2,2-trimethylpropyl]-1H-benzotriazol-5-ol;
4-bromo-1-[(1R)-1,2,2-trimethylpropyl]-1H-benzotriazol-5-ol;
4,6-dibromo-1-[(1R)-1,2-dimethylpropyl]-1H-benzotriazol-5-ol;
4-bromo-1-[(1R)-1,2-dimethylpropyl]-1H-benzotriazol-5-ol;
4-bromo-5-(3-bromopropoxy)-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(prop-2-en-1-yloxy)-1H-benzotriazole;
5-{[3,5-bis(trifluoromethyl)benzyl]oxy}-4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazole;
2-{[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}-1-phenylethanone;
5-(benzyloxy)-4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazole;
methyl 4-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)benzoate;
methyl 3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)benzoate;
4-bromo-1-(2,2-dimethylpropyl)-5-(1-phenylethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(2-fluoroethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(trifluoromethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-{[6-(trifluoromethyl)pyridin-3-yl]methoxy}-1H-benzotriazole;
methyl 3′-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-4-hydroxybiphenyl-3-carboxylate;
3-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyridine-2-carbonitrile;
2-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyridine-3-carbonitrile;
3-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]-5-(1-hydroxy-1-methylethyl)pyridine-2-carbonitrile;
2-{4-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyridin-3-yl}propan-2-ol;
2-{3-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyridin-2-yl}propan-2-ol;
2-{4-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyridin-2-yl}propan-2-ol;
3-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]-5-methylpyridine-2-carbonitrile;
6-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-yl]oxy}methyl)phenyl]pyridine-2-carbonitrile;
4-bromo-1-(2,2-dimethylpropyl)-5-({3-[1-(1,1-dioxidothio-morpholin-4-yl)ethyl]pyridin-2-yl}oxy)-1H-benzotriazole;
3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenol;
5-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyrimidine-2-carbonitrile;
5-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyrimidine-2-carboxamide;
5-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]pyrimidin-2-ol;
4-bromo-1-(2,2-dimethylpropyl)-5-{[3-(5-methoxypyridin-2-yl)benzyl]oxy}-1H-benzotriazole;
4-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)phenyl]-1H-pyrazole-3-carbonitrile;
4-bromo-1-(2,2-dimethylpropyl)-5-(pyrazin-2-ylmethoxy)-1H-1,2,3-benzotriazole;
4-bromo-5-[1-(3-bromophenyl)ethoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(1S)-1-pyridin-2-ylethoxy]-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(1-pyrazin-2-ylethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(pyrazolo[1,5-a]pyridin-7-ylmethoxy)-1H-benzotriazole;
4-[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]benzonitrile;
4-bromo-1-(2,2-dimethylpropyl)-5-(pyrimidin-2-ylmethoxy)-1H-benzotriazole;
4-bromo-5-[(6-chloropyrazin-2-yl)methoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
Ethyl {[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}(phenyl)acetate;
4-bromo-1-(2,2-dimethylpropyl)-5-(1,3-oxazol-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(1R)-1-pyridin-2-ylethoxy]-1H-benzotriazole;
methyl 6-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridine-3-carboxylate;
methyl 6-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridine-2-carboxylate;
4-bromo-1-(2,2-dimethylpropyl)-5-[(1R)-1-phenylethoxy]-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(pyridin-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(1S)-1-phenylethoxy]-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(1-phenylpropoxy)-1H-benzotriazole;
4-chloro-1-(2,2-dimethylpropyl)-5-(pyrazin-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(6-fluoropyrazin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-5-[cyclopropyl(4-fluorophenyl)methoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-5-[1-(4-bromophenyl)ethoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(4-methyl-2-phenylpyrimidin-5-yl)methoxy]-1H-benzotriazole;
4-bromo-5-[(6-chloropyridin-3-yl)methoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-5-[(3,5-dimethyl-4-nitropyridin-2-yl)methoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-5-[(4-chloropyridin-2-yl)methoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(6-piperidin-1-ylpyridin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-5-[(6-bromopyridin-2-yl)methoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-5-[(5-bromopyridin-2-yl)methoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(2-methylpyridin-3-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(4-methoxy-3,5-dimethylpyridin-2-yl)methoxy]-1H-benzotriazole;
5-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyrimidine-2,4-diol;
5-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridin-2-amine;
N-[3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridin-2-yl]-2,2-dimethylpropanamide;
4-bromo-1-(2,2-dimethylpropyl)-5-(1-pyridin-4-ylethoxy)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(1-oxidopyridin-3-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(1-oxidopyridin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(pyridin-4-ylmethoxy)-1H-benzotriazole;
4-bromo-5-[1-(4-bromophenyl)-2,2,2-trifluoroethoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(3-fluoropyridin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-5-[(2-bromobenzyl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(2-fluorobenzyl)oxy]-1H-benzotriazole;
4-bromo-5-[(2-chlorobenzyl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-5-[(2,4-dichlorobenzyl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-5-[(2,5-dichlorobenzyl)oxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-{[2-(trifluoromethyl)benzyl]oxy}-1H-benzotriazole;
4-bromo-5-[1-(4-bromophenyl)ethoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-5-[1-(4-bromophenyl)ethoxy]-1-(2,2-dimethylpropyl)-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-[(2-methylpyridin-3-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(2,2-dimethylpropyl)-5-(1-pyridin-4-ylethoxy)-1H-benzotriazole;
methyl 6-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridine-2-carboxylate;
4-bromo-1-(2,2-dimethylpropyl)-5-[(2-methyl-1,3-thiazol-4-yl)methoxy]-1H-benzotriazole;
{[4-Bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}acetonitrile;
4-Bromo-1-(cyclopropylmethyl)-5-[(6-methoxypyridin-2-yl)methoxy]-1H-benzotriazole;
1-{[4-Bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3,3-dimethylbutan-2-one;
1-{[4-Bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3,3-dimethylbutan-2-ol;
1-{[4-Bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-N-hydroxy-3,3-dimethylbutan-2-imine;
tert-butyl-4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-hydroxypiperidine-1-carboxylate;
tert-butyl-4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-fluoropiperidine-1-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-{[3-fluoropiperidin-4-yl]oxy}-1-H-benzotriazole;
5-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)-1,3-oxazolidin-2-one;
4-bromo-1-(cyclopropylmethyl)-5-(pyridin-4-ylmethoxy)-1H-benzotriazole;
5-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)-3-(2,2,2-trifluoroethyl)-1,3-oxazolidin-2-one;
4-bromo-1-(cyclopropylmethyl)-5-{[(3R,4R)-3-fluoro-1-(2,2,2-trifluoroethyl)piperidin-4-yl]oxy}-1H-benzotriazole;
tert-butyl (3S,4R)-4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-fluoropiperidine-1-carboxylate;
tert-butyl 4-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)-3,6-dihydropyridine-1(2H)-carboxylate;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-morpholin-4-ylpropan-2-ol;
tert-butyl[1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-hydroxypropyl)piperidin-4-yl]carbamate;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-hydroxypropyl)piperidine-4-carbonitrile;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-(4-methoxypiperidin-1-yl)propan-2-ol;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-(4-fluoropiperidin-1-yl)propan-2-ol;
tert-butyl (3S,4S)-3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-4-hydroxypiperidine-1-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(2,2-difluoroethyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
5-[(1-acetylpiperidin-4-yl)methoxy]-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(2-methylpropanoyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-propanoylpiperidin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(methoxyacetyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-5-{[1-(cyclopropylcarbonyl)piperidin-4-yl]methoxy}-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(trifluoroacetyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(2,2,2-trifluoroethyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-pyrrolidin-1-ylpropan-2-ol;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-[4-(methylsulfonyl)piperazin-1-yl]propan-2-ol;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-[4-(ethylsulfonyl)piperazin-1-yl]propan-2-ol;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]propan-2-ol;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-hydroxypropyl)piperidin-4-ol;
1-(4-acetylpiperazin-1-yl)-3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propan-2-ol;
benzyl 4-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-hydroxypropyl)piperazine-1-carboxylate;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-[4-(phenylcarbonyl)piperazin-1-yl]propan-2-ol;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-[4-(phenylsulfonyl)piperazin-1-yl]propan-2-ol;
tert-butyl 4-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-hydroxypropyl)-1,4-diazepane-1-carboxylate;
1-azetidin-1-yl-3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propan-2-ol;
3-[4-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)piperidin-1-yl]-3-oxopropanenitrile;
tert-butyl (3S,4S)-4-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)-3,4-dihydroxypiperidine-1-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-[(1-methylpiperidin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-ethylpiperidin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-propylpiperidin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(2,2-dimethylpropyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(1-methylethyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
tert-butyl 4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}piperidine-1-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(3,3,3-trifluoropropyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(2,2,3,3-tetrafluoropropyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(trifluoroacetyl)piperidin-4-yl]oxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(2,2-difluoroethyl)piperidin-4-yl]oxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]oxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(2,2,2-trifluoroethyl)piperidin-4-yl]oxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-({1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}methoxy)-1H-benzotriazole;
tert-butyl 3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-4-oxopiperidine-1-carboxylate;
tert-butyl (3R,4R)-4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-hydroxypiperidine-1-carboxylate;
tert-butyl (3R,4R)-4-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)-3-hydroxypiperidine-1-carboxylate;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}cycloheptanone;
3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl acetate;
methyl 2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}butanoate;
4-bromo-1-(cyclopropylmethyl)-5-(1,3-thiazol-4-ylmethoxy)-1H-benzotriazole;
methyl 4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}butanoate;
5-(1H-benzotriazol-1-ylmethoxy)-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(ethoxymethoxy)-1H-benzotriazole;
{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl 2,2-dimethylpropanoate;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-N-methoxy-N-methylacetamide;
4-bromo-1-(cyclopropylmethyl)-5-[(3,5-dimethylisoxazol-4-yl)methoxy]-1H-benzotriazole;
5-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pentan-2-one;
ethyl 2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-methylpropanoate;
tert-butyl {[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}acetate;
4-bromo-1-(cyclopropylmethyl)-5-(1,3-dioxolan-2-ylmethoxy)-1H-benzotriazole;
methyl 4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-methylbutanoate;
4-bromo-1-(cyclopropylmethyl)-5-(tetrahydro-2H-pyran-4-yloxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(tetrahydrofuran-3-yloxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(isothiazol-3-ylmethoxy)-1H-benzotriazole;
3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}azepan-2-one;
4-bromo-1-(cyclopropylmethyl)-5-[(1-methyl-1H-1,2,4-triazol-3-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1,4-dioxan-2-ylmethoxy)-1H-benzotriazole;
4-bromo-5-[(6-chloropyridazin-3-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(imidazo[1,2-a]pyrimidin-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(1,3-dioxolan-2-yl)ethoxy]-1H-benzotriazole;
tert-butyl 2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propanoate;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-N-(1-methylethyl)acetamide;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}cyclohexanone;
4-bromo-1-(cyclopropylmethyl)-5-[(1-ethyl-1H-imidazol-2-yl)methoxy]-1H-benzotriazole;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-N,N-diethylacetamide;
4-bromo-1-(cyclopropylmethyl)-5-[(4-methyl-1,3-thiazol-5-yl)methoxy]-1H-benzotriazole;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-N-tert-butylacetamide;
4-bromo-1-(cyclopropylmethyl)-5-[2-(1,3-dioxan-2-yl)ethoxy]-1H-benzotriazole;
{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl butanoate;
[6-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridin-2-yl]methanol;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-methylpropanamide;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}cyclopentanone;
ethyl 2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3-methylbutanoate;
4-bromo-5-(but-3-en-1-yloxy)-1-(cyclopropylmethyl)-1H-benzotriazole;
4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}butane-1,2-diol;
4-bromo-1-(cyclopropylmethyl)-5-[3-(4,4-difluoropiperidin-1-yl)propoxy]-1H-benzotriazole;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-1-pyridin-2-ylethanone;
4-bromo-1-(cyclopropylmethyl)-5-{[2-(1-methylethyl)-1,3-thiazol-4-yl]methoxy}-1H-benzotriazole;
tert-butyl 4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}butanoate;
4-bromo-1-(cyclopropylmethyl)-5-(3-morpholin-4-ylpropoxy)-1H-benzotriazole;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3,3-dimethylbutan-2-one;
3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propan-1-ol;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)-3-methylimidazolidine-2,4-dione;
4-bromo-1-(cyclopropylmethyl)-5-[(5-methylimidazo[1,2-a]pyridin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-5-[(3-tert-butyl-1,2,4-oxadiazol-5-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-5-[(5-tert-butyl-1,3,4-oxadiazol-2-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-N,N-dimethylbutanamide;
4-bromo-1-(cyclopropylmethyl)-5-[(3-methylpyridin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(5-ethyl-1,3,4-oxadiazol-2-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[2-(1-methylethyl)-1,3-oxazol-4-yl]methoxy}-1H-benzotriazole;
4-bromo-5-[(2-chloro-1,3-thiazol-5-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(4-methyl-1,3-thiazol-2-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[4-(1H-pyrazol-1-yl)benzyl]oxy}-1H-benzotriazole;
N-(4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}cyclohexyl)acetamide;
4-bromo-1-(cyclopropylmethyl)-5-{[(2S)-2-methoxycyclohexyl]oxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[3-(1,1-dioxidothiomorpholin-4-yl)propoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(4-methoxypyridin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-5-[3-(4-bromo-1H-pyrazol-1-yl)propoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(6-methoxypyridin-2-yl)methoxy]-1H-benzotriazole;
N-[5-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridin-2-yl]-2,2-dimethylpropanamide;
4-bromo-5-[(2-chloro-5-fluoropyridin-3-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[6-(1H-pyrazol-1-yl)pyridin-3-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(prop-2-en-1-yloxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-methoxyethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(tetrahydro-2H-pyran-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(pyridin-4-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(2-methylpyridin-3-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(thiophen-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-methyl-1H-pyrazol-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1H-imidazol-4-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(tetrahydro-2H-pyran-3-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1,4-dioxan-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1,3-oxazol-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1,3-oxazol-5-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-methyl-1H-imidazol-2-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(thiophen-3-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-fluoro-1-(fluoromethyl)ethoxy]-1H-benzotriazole;
3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propane-1,2-diol;
4-bromo-1-(cyclopropylmethyl)-5-(2-ethoxyethoxy)-1H-benzotriazole;
2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl acetate;
ethyl 2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}butanoate;
4-bromo-1-(cyclopropylmethyl)-5-(1,3-thiazol-2-ylmethoxy)-1H-benzotriazole;
4-bromo-5-(cyclobutylmethoxy)-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(3-methoxypropoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(furan-3-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(3,4-dihydro-2H-pyran-2-ylmethoxy)-1H-benzotriazole;
methyl 3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2,2-dimethylpropanoate;
4-bromo-1-(cyclopropylmethyl)-5-[2-(1H-imidazol-1-yl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(4-methyl-1,3-thiazol-5-yl)ethoxy]-1H-benzotriazole;
methyl 2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propanoate;
4-bromo-5-[(6-chloropyridin-3-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(5-methyl-1,3-dioxan-5-yl)methoxy]-1H-benzotriazole;
methyl (2S)-3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-2-methylpropanoate;
4-bromo-1-(cyclopropylmethyl)-5-[(6-methylpyridin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-5-[(2-chloropyridin-3-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-morpholin-4-ylpropoxy)-1H-benzotriazole;
(5S)-5-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)dihydrofuran-2(3H)-one;
4-bromo-1-(cyclopropylmethyl)-5-(1-pyridin-2-ylethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(1-methylethoxy)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(1-methylpyrrolidin-2-yl)ethoxy]-1H-benzotriazole;
ethyl {[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}acetate;
4-bromo-1-(cyclopropylmethyl)-5-(2,2-dimethoxyethoxy)-1H-benzotriazole;
5-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pentan-2-one;
4-bromo-1-(cyclopropylmethyl)-5-[(1-propyl-1H-1,2,4-triazol-5-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(isoxazol-3-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(isoxazol-4-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{3-[(2S)-tetrahydrofuran-2-yl]propoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-isoxazol-4-ylethoxy)-1H-benzotriazole;
3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyrrolidin-2-one;
4-bromo-1-(cyclopropylmethyl)-5-(oxetan-3-yloxy)-1H-benzotriazole;
3-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}pyrrolidin-1-yl)propanenitrile;
4-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)morpholin-3-one;
4-bromo-1-(cyclopropylmethyl)-5-[(3-prop-2-en-1-yloxetan-3-yl)methoxy]-1H-benzotriazole;
7-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}Spiro[2.5]octan-4-one;
4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}cyclohexanecarbonitrile;
4-bromo-1-(cyclopropylmethyl)-5-(imidazo[1,2-a]pyridin-3-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(3-ethylisoxazol-5-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(tetrahydro-2H-pyran-4-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2,2-difluoroethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(3-ethyloxetan-3-yl)methoxy]-1H-benzotriazole;
1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)pyrrolidine-2,5-dione;
4-bromo-1-(cyclopropylmethyl)-5-[(3R)-tetrahydro-2H-pyran-3-ylmethoxy]-1H-benzotriazole;
1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)imidazolidine-2,4-dione;
1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)-3-methylimidazolidine-2,4-dione;
ethyl N-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)glycinate;
4-bromo-1-(cyclopropylmethyl)-5-[2-(methylsulfanyl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(3-methyloxetan-3-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2,3-dimethoxypropoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{[(3S)-3-methoxybutyl]oxy}-1H-benzotriazole;
methyl {[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}acetate;
4-bromo-1-(cyclopropylmethyl)-5-(pyridin-2-ylmethoxy)-1H-benzotriazole;
1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)imidazolidin-2-one;
(5R)-5-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)pyrrolidin-2-one;
4-bromo-1-(cyclopropylmethyl)-5-[(3-methoxybenzyl)oxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-oxidopyridin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-pyridin-2-ylethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(pyrimidin-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(3-fluoropyridin-2-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(isoxazol-5-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(tetrahydrofuran-2-ylmethoxy)-1H-benzotriazole;
4-bromo-5-[(2-chloropyridin-4-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-5-[(2-chloro-1,3-thiazol-5-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(5-methylisoxazol-3-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-methyl-1H-imidazol-5-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(methylsulfonyl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(methylsulfinyl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-ethoxy-1-methylethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(4H-1,2,4-triazol-4-yl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(1-ethyl-1H-imidazol-5-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1,3-thiazol-5-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1,3-dioxolan-4-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(furan-2-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-methoxy-1-methylethoxy)-1H-benzotriazole;
4-bromo-5-[(4-chloropyridin-2-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(4,4-difluoropiperidin-1-yl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{2-[4-(trifluoromethyl)piperidin-1-yl]ethoxy}-1H-benzotriazole;
1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)piperidine-4-carbonitrile;
1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)-4-fluoropiperidine-4-carbonitrile;
4-bromo-1-(cyclopropylmethyl)-5-[2-(3,3-difluoropyrrolidin-1-yl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{2-[(3R,4R)-3,4-difluoropyrrolidin-1-yl]ethoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{2-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]ethoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{2-[2-(trifluoromethyl)piperidin-1-yl]ethoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(3,3-difluoropiperidin-1-yl)ethoxy]-1H-benzotriazole;
5-[2-(4-benzyl-4-fluoropiperidin-1-yl)ethoxy]-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;
1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)-4-phenylpiperidine-4-carbonitrile;
ethyl 1-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)-4-fluoropiperidine-4-carboxylate;
5-[2-(4-acetylpiperazin-1-yl)ethoxy]-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;
4-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)piperazin-2-one;
4-bromo-1-(cyclopropylmethyl)-5-(2-morpholin-4-ylethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{2-[4-(methylsulfonyl)piperazin-1-yl]ethoxy}-1H-benzotriazole;
4-bromo-5-(2-tert-butoxyethoxy)-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[2-(cyclopropyloxy)ethoxy]-1H-benzotriazole;
4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-N,N-dimethylbutanamide;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-4,4-dimethylpentan-2-one;
N-[4-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)-1,3-thiazol-2-yl]acetamide;
4-bromo-1-(cyclopropylmethyl)-5-{[3-(trifluoromethoxy)benzyl]oxy}-1H-benzotriazole;
tert-butyl (2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)carbamate;
4-bromo-1-(cyclopropylmethyl)-5-[(1,3-dimethyl-1H-pyrazol-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(3-methylpyridin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(pyridin-3-ylmethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[(2,6-dichloropyridin-4-yl)methoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-pyridin-4-ylethoxy)-1H-benzotriazole;
methyl 5-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)-1H-imidazole-4-carboxylate;
ethyl 4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}cyclohexanecarboxylate;
4-bromo-1-(cyclopropylmethyl)-5-[(5,6-dichloropyridin-3-yl)methoxy]-1H-benzotriazole;
5-[(1-benzyl-1H-imidazol-5-yl)methoxy]-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;
4-bromo-5-[(5-bromopyridin-3-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
tert-butyl (2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)methylcarbamate;
4-bromo-5-[(6-bromopyridin-2-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
tert-butyl 3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}piperidine-1-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-{[5-(trifluoromethyl)pyridin-2-yl]methoxy}-1H-benzotriazole;
methyl 6-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridine-2-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-[(tetrahydro-2H-pyran-2-ylmethoxy)methyl]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-ethoxy-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[3-(4,4-difluoropiperidin-1-yl)propoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{3-[(3S)-3-fluoropyrrolidin-1-yl]propoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(3-piperidin-1-ylpropoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{3-[(3S,4S)-3,4-difluoropyrrolidin-1-yl]propoxy}-1H-benzotriazole;
4-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)piperazin-2-one;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)-4-phenylpiperidine-4-carbonitrile;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)piperidine-4-carbonitrile;
4-bromo-1-(cyclopropylmethyl)-5-[3-(3-fluoropiperidin-1-yl)propoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{3-[3-(fluoromethyl)pyrrolidin-1-yl]propoxy}-1H-benzotriazole;
ethyl 1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)-4-fluoropiperidine-4-carboxylate;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)-4-fluoropyrrolidin-3-ol;
4-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)-1-methylpiperazin-2-one;
4-bromo-1-(cyclopropylmethyl)-5-[3-(4,4-dimethylpiperidin-1-yl)propoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[3-(3,3-difluoropiperidin-1-yl)propoxy]-1H-benzotriazole;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)-4-pyridin-2-ylpiperidine-4-carbonitrile;
1-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)-4-fluoropiperidine-4-carbonitrile;
4-bromo-1-(cyclopropylmethyl)-5-{3-[4-(trifluoromethyl)piperidin-1-yl]propoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{3-[4-(methylsulfonyl)piperazin-1-yl]propoxy}-1H-benzotriazole;
5-[3-(4-acetylpiperazin-1-yl)propoxy]-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;
(2Z)-1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3,3-dimethylbutan-2-one oxime;
1-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}-3,3-dimethylbutan-2-ol;
4-bromo-1-(cyclopropylmethyl)-5-[2-(1H-pyrazol-1-yl)ethoxy]-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(2-methoxybutoxy)-1H-benzotriazole;
1-methylethyl {[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}acetate;
4-bromo-1-(cyclopropylmethyl)-5-(3-pyridin-2-ylpropoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1-methyl-2-morpholin-4-ylethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(3-pyridin-3-ylpropoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-(1,4-dioxaspiro[4.5]dec-8-yloxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-[3-(1H-imidazol-1-yl)propoxy]-1H-benzotriazole;
4-bromo-5-[(2-bromo-1,3-thiazol-4-yl)methoxy]-1-(cyclopropylmethyl)-1H-benzotriazole;
5-(benzyloxy)-1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazole;
1-(2,2-dimethylpropyl)-5-(pyrazin-2-ylmethoxy)-1H-benzotriazole-4-carbonitrile;
3′-({[4-cyano-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-4-hydroxybiphenyl-3-carboxylic acid;
5-{[3-(2-cyanopyrimidin-5-yl)benzyl]oxy}-1-(2,2-dimethylpropyl)-1H-benzotriazole-4-carbonitrile;
1-(cyclopropylmethyl)-5-methoxy-1H-benzotriazole-4-carbonitrile;
4-bromo-1-(cyclopropylmethyl)-5-(3-piperazin-1-ylpropoxy)-1H-benzotriazole;
(2S)-1-[4-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)piperazin-1-yl]-1-oxopropan-2-ol;
4-bromo-1-(cyclopropylmethyl)-5-{3-[4-(methylsulfonyl)piperazin-1-yl]propoxy}-1H-benzotriazole;
5-[3-(4-acetylpiperazin-1-yl)propoxy]-4-bromo-1-(cyclopropylmethyl)-1H-benzotriazole;
tert-butyl 4-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)piperazine-1-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-(2-piperazin-1-ylethoxy)-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{2-[4-(methylsulfonyl)piperazin-1-yl]ethoxy}-1H-benzotriazole;
tert-butyl 4-({[4-chloro-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)piperidine-1-carboxylate;
4-bromo-1-(cyclopropylmethyl)-5-{[1-(isoxazol-3-ylcarbonyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
(2S)-1-[4-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)piperidin-1-yl]-1-oxopropan-2-ol;
tert-butyl 3-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)piperidine-1-carboxylate;
tert-butyl 3-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)pyrrolidine-1-carboxylate;
tert-butyl (2R)-2-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)pyrrolidine-1-carboxylate;
tert-butyl 3-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)azetidine-1-carboxylate;
tert-butyl 4-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)piperidine-1-carboxylate;
4-chloro-1-(cyclopropylmethyl)-5-{[1-(isoxazol-3-ylcarbonyl)piperidin-4-yl]methoxy}-1H-benzotriazole;
4-bromo-1-(cyclopropylmethyl)-5-{3-[4-(isoxazol-3-ylcarbonyl)piperazin-1-yl]propoxy}-1H-benzotriazole;
4-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}butan-2-ol;
tert-butyl (2S)-2-({[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}methyl)pyrrolidine-1-carboxylate;
tert-butyl 4-(2-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}ethyl)piperazine-1-carboxylate;
tert-butyl 4-(3-{[4-bromo-1-(cyclopropylmethyl)-1H-benzotriazol-5-yl]oxy}propyl)piperazine-1-carboxylate;
4-chloro-1-(cyclopropylmethyl)-5-{[1-(isoxazol-3-ylcarbonyl)-4-methylpiperidin-4-yl]methoxy}-1H-benzotriazole;
1-[4-({[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]oxy}methyl)-4-methylpiperidin-1-yl]-1-oxopropan-2-ol;
2-[4-({[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]oxy}methyl)-4-methylpiperidin-1-yl]-2-oxoethanol; and
5-(Benzyloxy)-1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazole
or a pharmaceutically acceptable salt of any of the foregoing compounds.

### Claim 10

A compound selected from the following group:
3′-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-5-fluorobiphenyl-3-carboxylic acid;
3′-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)-4-hydroxybiphenyl-3-carboxylic acid;
3-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)benzoic acid;
4-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)benzoic acid;
6-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridine-3-carboxylic acid; and
6-({[4-bromo-1-(2,2-dimethylpropyl)-1H-benzotriazol-5-yl]oxy}methyl)pyridine-2-carboxylic acid;
or a pharmaceutically acceptable salt of any of the foregoing compounds.

### Claim 11 (depends on 1)

A pharmaceutical composition comprising a compound according to claim 1, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.

### Claim 12 (depends on 3)

A pharmaceutical composition comprising a compound according to claim 3, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.

### Claim 13 (depends on 6)

A pharmaceutical composition comprising a compound according to claim 6, or a pharmaceutically acceptable salt thereof, in combination with a pharmaceutically acceptable carrier.