Plasminogen activator inhibitor-1 inhibitor

A compound represented by Formula (I) or a salt thereof:

• wherein R1 represents halogen, R2 represents hydrogen, halogen, C1-6-alkyl, C3-8-cycloalkyl, C3-8-cycloalkyl-C1-6-alkyl, C3-8-cycloalkenyl, C2-6-alkynyl, C3-8-cycloalkyl-C2-6-alkynyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• X represents —CH═CH—;
• A represents a group represented by the following Formula (II):
• wherein R3 and R4 are the same or different, and each represents hydrogen, substituted or unsubstituted C1-6-alkyl, or CF3;
• T represents a single bond;
• D represents substituted or unsubstituted aryl, heteroaryl except pyrazolyl, or
• benzo-condensed heteroaryl;
• substituted or unsubstituted C4-8-cycloalkyl;
• substituted or unsubstituted C3-8-cycloalkenyl or heterocycloalkenyl;
• or adamantyl;
• q is 1 ;
• L represents a single bond;
• B is located at ortho position on the benzene ring to which imino is bound, and is COOR9
• wherein R9 represents hydrogen;
• or a group converted to hydrogen in vivo, which is selected from the group consisting of C1-6-alkyl, aryl, aralkyl, —CH(R10)—O—CO—R11, —CH(R10)—O—CO—OR11, and a (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl group represented by the following formula:
• wherein R10 is hydrogen or C1-6-alkyl, R11 is C1-6-alkyl or C3-8-cycloalkyl, and R12 is C1-6 alkyl;
• or
• a heterocyclic group represented by any of the following Formulae (XI)-(XIII):
• wherein Z represents oxygen or sulfur,
• provided that the following compounds and salts thereof are excluded:
• 2-[(biphenyl-4-ylcarbonyl)amino]-5-chlorobenzoic acid, and 5-chloro-2-({[4-(1H-pyrrol-1-yl)phenyl]carbonyl}amino)benzoic acid.