# US 8,785,472 B2 · Use of dextromethorphan in treating addictive behavior or bipolar disorder

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- Number: US 8,785,472 B2
- Document ID: US8785472B2
- Status: Granted
- Kind: B2
- Application number: 12/857,956
- Filed: 2010-08-17
- Published: 2011-11-17
- Granted: 2014-07-22
- Earliest claimed: 2010-05-11
- Assignees: National Cheng Kung University
- Applicants: Ru-Band Lu
- Inventors: Ru-Band Lu
- Web page: https://patentgrep.com/patent/US8785472B2

## CPC

- A61K 31/485: Morphinan derivatives, e.g. morphine, codeine
- A61P 25/18: Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A61P 25/30: for treating abuse or dependence
- A61P 25/36: Opioid-abuse
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention provides a method for treating addictive behavior, comprising administering Dextromethorphan (DM) to a subject suffering addictive behavior. The present invention also provides a method for treating bipolar disorder, comprising administering Dextromethorphan (DM) to a subject suffering bipolar disorder.

## Claims

### Claim 1

A method for treating addictive behavior, consisting of administrating Dextromethorphan (DM) to a subject suffering from addictive behavior, wherein the dose of Dextromethorphan (DM) is equal to or lower than 60 mg/day.

### Claim 2 (depends on 1)

The method of claim 1, which reduces opioid tolerance.

### Claim 3 (depends on 1)

The method of claim 1, which decreases methadone use.

### Claim 4 (depends on 1)

The method of claim 1, which reduces withdrawal symptoms.

### Claim 5 (depends on 1)

The method of claim 1, which decreases relapse rate of opioid use.

### Claim 6 (depends on 1)

The method of claim 1, wherein the subject is human.

### Claim 7

A method for treating bipolar disorder, comprising administrating Dextromethorphan (DM) to a subject suffering from bipolar disorder, wherein the dose of Dextromethorphan (DM) is equal to or lower than 60 mg/day.

### Claim 8 (depends on 7)

The method of claim 7, wherein the bipolar disorder is bipolar I (BP-I) or bipolar II (BP-II).

### Claim 9 (depends on 7)

The method of claim 7, which decreases plasma level of TNF-α or IL-8 in the subject.

### Claim 10 (depends on 7)

The method of claim 7, wherein the subject is human.

### Claim 11 (depends on 1)

The method of claim 1, which reduces opioid craving.