# US 8,785,471 B2 · Pharmaceutical composition containing ferulic acid and matrine compounds, the preparation and the use thereof

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 8,785,471 B2
- Document ID: US8785471B2
- Status: Granted
- Kind: B2
- Application number: 13/058,738
- Filed: 2009-09-09
- Published: 2011-06-16
- Granted: 2014-07-22
- Earliest claimed: 2008-09-11
- Assignees: Qingdao Qiyuan Bio-Technologies Co., Ltd.
- Applicants: Xiaojie Sun; Weifu Ma
- Inventors: Xiaojie Sun; Weifu Ma
- Web page: https://patentgrep.com/patent/US8785471B2

## CPC

- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 9/1652: {Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623)}
- A61K 9/2059: {Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin}
- A61K 9/2077: {Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets}
- A61K 31/4375: the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K 47/32: Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone}
- A61P 1/14: Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A61P 3/06: Antihyperlipidemics
- A61P 7/02: Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A61P 9/12: Antihypertensives
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/08: for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A61P 17/00: Drugs for dermatological disorders
- A61P 17/04: Antipruritics
- A61P 17/06: Antipsoriatics
- A61P 17/10: Anti-acne agents
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- A61P 35/00: Antineoplastic agents
- A61P 37/04: Immunostimulants
- A61P 39/06: Free radical scavengers or antioxidants
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Preparation and usage of a pharmaceutical composition containing ferulic acid and matrine compounds are described. The ingredients ferulic acid and matrine compounds in this pharmaceutical composition have synergistic effects which can obviously improve the pharmacology effects of both the ferulic acid and matrine compounds. Moreover, the pharmaceutical composition can significantly increase the aqueous and fat solubility of the individual ingredients.

## Claims

### Claim 1

A pharmaceutical composition for oral or topical administration consisting of a combination of ferulic acid and matrine compounds, wherein said matrine compound consists of either oxymatrine or a combination of oxymatrine and matrine, and wherein a mole ratio between the ferulic acid and matrine compounds within the composition is 1:0.1 to 1:10.

### Claim 2 (depends on 1)

The composition as claimed in claim 1, wherein any of the ferulic acid, oxymatrine or matrine are present as an inorganic salt.

### Claim 3

A method of preparing a pharmaceutical composition for oral or topical administration, wherein the pharmaceutical composition consists of a combination of ferulic acid and matrine compounds, and a pharmaceutical excipient, wherein said matrine compound consists of either oxymatrine or a combination of oxymatrine and matrine, the method comprising adding a pharmaceutical excipient to the ferulic acid and matrine compounds to produce a pharmaceutical preparation, wherein the mole ratio of ferulic acid to matrine compounds in the composition is between 1:0.1 to 1:10.

### Claim 4 (depends on 3)

The method as claimed in claim 3, wherein the pharmaceutical excipient is selected from the group consisting of water, starch, magnesium stearate, carbopol, propylene glycol and methylparaben.

### Claim 5

A pharmaceutical composition for oral or topical administration consisting an active ingredient consisting of a combination of ferulic acid and matrine compounds, and a pharmaceutical excipient, wherein said matrine compound consists of either oxymatrine or a combination of oxymatrine and matrine, and wherein a mole ratio between the ferulic acid and matrine compounds within the composition is 1:0.1 to 1:10.

### Claim 6 (depends on 5)

The composition as claimed in claim 5, wherein any of the ferulic acid, oxymatrine or matrine are present as an inorganic salt.

### Claim 7 (depends on 5)

The composition as claimed in claim 5, wherein the pharmaceutical excipient is selected from the group consisting of water, starch, magnesium stearate, carbopol, propylene glycol, and methylparaben.