# US 8,785,464 B2 · Pyrimidine derivatives that inhibit FAK/PTK2

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- Number: US 8,785,464 B2
- Document ID: US8785464B2
- Status: Granted
- Kind: B2
- Application number: 14/049,575
- Filed: 2013-10-09
- Published: 2014-02-06
- Granted: 2014-07-22
- Earliest claimed: 2008-11-24
- Assignees: Boehringer Ingelheim International GmbH
- Applicants: Heinz Stadtmueller; Bodo Betzemeier; Ioannis Sapountzis
- Inventors: Heinz Stadtmueller; Bodo Betzemeier; Ioannis Sapountzis
- Web page: https://patentgrep.com/patent/US8785464B2

## CPC

- C07D 417/14: containing three or more hetero rings
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 35/00: Antineoplastic agents
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- C07D 239/47: One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07D 405/14: containing three or more hetero rings
- C07D 413/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention includes compounds of general formula (1) wherein A, X, R1 and R2 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, and their use for preparing a medicament having the above-mentioned properties.

## Claims

### Claim 1

A compound selected from the group consisting of:
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or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier or diluent.

### Claim 3 (depends on 1)

A method for treating prostate carcinoma which comprises administering to a host suffering from such condition a therapeutically effective amount of a compound according to claim 1.