# US 8,785,412 B2 · Method for inducing cancer cell apoptosis or inhibiting the cancer cell migration

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- Number: US 8,785,412 B2
- Document ID: US8785412B2
- Status: Granted
- Kind: B2
- Application number: 13/195,143
- Filed: 2011-08-01
- Published: 2012-10-11
- Granted: 2014-07-22
- Earliest claimed: 2011-04-08
- Assignees: National Tsing Hua University
- Applicants: Horng-Dar Wang; Chiou-Hwa Yuh; Shih-Ci Ciou; Yu-Ting Chou
- Inventors: Horng-Dar Wang; Chiou-Hwa Yuh; Shih-Ci Ciou; Yu-Ting Chou
- Web page: https://patentgrep.com/patent/US8785412B2

## CPC

- A61K 38/02: Peptides of undefined number of amino acids; Derivatives thereof
- A61K 31/7088: Compounds having three or more nucleosides or nucleotides
- A61K 31/713: Double-stranded nucleic acids or oligonucleotides
- A61P 35/00: Antineoplastic agents
- C12N 15/1137: {against enzymes (viral enzymes C12N15/1131; receptors C12N15/1138)}
- C12N 2310/14: interfering nucleic acids [NA]
- C12N 2320/31: Combination therapy
- C12Y 503/01006: Ribose-5-phosphate isomerase (5.3.1.6)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12Y: ENZYMES

## Abstract

The present invention is related to a method for inducing the cancer cell apoptosis or inhibiting the cancer cell migration by inhibiting the expression of ribose-5-phosphate isomerase A.

## Claims

### Claim 1

A method for inducing the cancer cell apoptosis by the way of adding a siRNA to inhibiting the expression of ribose-5-phosphate isomerase A in said cancer cell, wherein said cancer cell is colon cancer cell or hepatic cancer cell.

### Claim 2 (depends on 1)

The method of claim 1, wherein the way of inhibiting the expression of ribose-5-phosphate isomerase A is to knockdown a ribose-5-phosphate isomerase (RPI) gene in said cell.

### Claim 3

A method for inhibiting the cancer cell migration by the way of adding a siRNA to inhibiting the expression of ribose-5-phosphate isomerase A in said cancer cell, wherein said cancer cell is colon cancer cell or hepatic cancer cell.

### Claim 4 (depends on 3)

The method of claim 3, wherein the way of inhibiting the expression of ribose-5-phosphate isomerase A is to knockdown a ribose-5-phosphate isomerase (RPI) gene in said cell.

### Claim 5

A method of enhancing the sensitivity of cancer cells to chemotherapeutic agents by the way of adding a siRNA to inhibiting the expression of ribose-5-phosphate isomerase A in said cancer cell, wherein said cancer cell is colon cancer cell or hepatic cancer cell.